Investigating Approaches to Estimating Covariate Effects in Growth Mixture Modeling: A Simulation Study.

Researchers continue to be interested in efficient, accurate methods of estimating coefficients of covariates in mixture modeling. Including covariates related to the latent class analysis not only may improve the ability of the mixture model to clearly differentiate between subjects but also makes interpretation of latent group membership more meaningful. Very few studies have been conducted that compare the performance of various approaches to estimating covariate effects in mixture modeling, and fewer yet have considered more complicated models such as growth mixture models where the latent class variable is more difficult to identify. A Monte Carlo simulation was conducted to investigate the performance of four estimation approaches: (1) the conventional three-step approach, (2) the one-step maximum likelihood (ML) approach, (3) the pseudo class (PC) approach, and (4) the three-step ML approach in terms of their ability to recover covariate effects in the logistic regression class membership model within a growth mixture modeling framework. Results showed that when class separation was large, the one-step ML approach and the three-step ML approach displayed much less biased covariate effect estimates than either the conventional three-step approach or the PC approach. When class separation was poor, estimation of the relation between the dichotomous covariate and latent class variable was severely affected when the new three-step ML approach was used.