Literature DB >> 29795760

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.

Andrea Angeli1, Lorenzo di Cesare Mannelli2, Elena Trallori2, Thomas S Peat3, Carla Ghelardini2, Fabrizio Carta1, Claudiu T Supuran1.   

Abstract

A series of novel selenides bearing benzenesulfonamide moieties was synthesized and investigated for their inhibition on six human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoforms such as the physiologically relevant hCA I, II, VA, VB, VII, and IX and the X-ray complex in adduct with hCA II for some of them investigated. These enzymes are involved in a variety of diseases including glaucoma, retinitis pigmentosa, epilepsy, arthritis, metabolic disorders, and cancer. The investigated compounds showed potent inhibitory action against hCA VA, VII, and IX, in the low nanomolar range, thus making them of interest for the development of isoform-selective inhibitors and as candidates for various biomedical applications.

Entities:  

Year:  2018        PMID： 29795760      PMCID： PMC5949733          DOI： 10.1021/acsmedchemlett.8b00076

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  31 in total

Review 1.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.

Authors:  Claudiu T Supuran
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

2.  Resveratrol-based benzoselenophenes with an enhanced antioxidant and chain breaking capacity.

Authors:  Damiano Tanini; Lucia Panzella; Riccardo Amorati; Antonella Capperucci; Elio Pizzo; Alessandra Napolitano; Stefano Menichetti; Marco d'Ischia
Journal:  Org Biomol Chem       Date:  2015-04-22       Impact factor: 3.876

3.  Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.

Authors:  Andrea Angeli; Fabrizio Carta; Gianluca Bartolucci; Claudiu T Supuran
Journal:  Bioorg Med Chem       Date:  2017-05-09       Impact factor: 3.641

4.  Proliferative retinopathy in type 1 diabetes is associated with cerebral microbleeds, which is part of generalized microangiopathy.

Authors:  Jorn Woerdeman; Eelco van Duinkerken; Mike P Wattjes; Frederik Barkhof; Frank J Snoek; Annette C Moll; Martin Klein; Michiel P de Boer; Richard G Ijzerman; Erik H Serné; Michaela Diamant
Journal:  Diabetes Care       Date:  2013-12-06       Impact factor: 19.112

5.  Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.

Authors:  Chandra Bhushan Mishra; Shikha Kumari; Andrea Angeli; Simona Maria Monti; Martina Buonanno; Manisha Tiwari; Claudiu T Supuran
Journal:  J Med Chem       Date:  2017-03-14       Impact factor: 7.446

6.  Topiramate Protects Pericytes from Glucotoxicity: Role for Mitochondrial CA VA in Cerebromicrovascular Disease in Diabetes.

Authors:  Ping Patrick; Tulin O Price; Ana L Diogo; Nader Sheibani; William A Banks; Gul N Shah
Journal:  J Endocrinol Diabetes       Date:  2015

7.  Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.

Authors:  Isao Nishimori; Daniela Vullo; Alessio Innocenti; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Journal:  Bioorg Med Chem Lett       Date:  2005-09-01       Impact factor: 2.823

8.  Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.

Authors:  Gul N Shah; Timothy S Rubbelke; Joshua Hendin; Hien Nguyen; Abdul Waheed; James D Shoemaker; William S Sly
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-15       Impact factor: 11.205

9.  Neurodegenerative disease: Diabetes, microvascular pathology and Alzheimer disease.

Authors:  Raj N Kalaria
Journal:  Nat Rev Neurol       Date:  2009-06       Impact factor: 42.937

10.  Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.

Authors:  Sally-Ann Poulsen; Brendan L Wilkinson; Alessio Innocenti; Daniela Vullo; Claudiu T Supuran
Journal:  Bioorg Med Chem Lett       Date:  2008-07-10       Impact factor: 2.823
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  3 in total

1.  Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice.

Authors:  Laura Micheli; Lara Testai; Andrea Angeli; Donatello Carrino; Alessandra Pacini; Francesco Margiotta; Lorenzo Flori; Claudiu T Supuran; Vincenzo Calderone; Carla Ghelardini; Lorenzo Di Cesare Mannelli
Journal:  Int J Mol Sci       Date:  2022-06-02       Impact factor: 6.208

2.  Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.

Authors:  Andrea Angeli; Elena Trallori; Fabrizio Carta; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Claudiu T Supuran
Journal:  ACS Med Chem Lett       Date:  2018-08-29       Impact factor: 4.345

3.  Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria.

Authors:  Andrea Angeli; Mariana Pinteala; Stelian S Maier; Bogdan C Simionescu; Andrea Milaneschi; Ghulam Abbas; Sonia Del Prete; Clemente Capasso; Antonella Capperucci; Damiano Tanini; Fabrizio Carta; Claudiu T Supuran
Journal:  Int J Mol Sci       Date:  2020-01-17       Impact factor: 5.923
  3 in total

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