Anton Holmgren1,2, Aimon Niklasson3, Andreas F M Nierop4, Lars Gelander3, A Stefan Aronson5, Agneta Sjöberg6, Lauren Lissner7, Kerstin Albertsson-Wikland8. 1. Göteborg Pediatric Growth Research Center (GP-GRC), Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. anton.holmgren@regionhalland.se. 2. Department of Pediatrics, Halmstad Hospital, Halmstad, Sweden. anton.holmgren@regionhalland.se. 3. Göteborg Pediatric Growth Research Center (GP-GRC), Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 4. Muvara bv, Multivariate Analysis of Research Data, Leiderdorp, The Netherlands. 5. Department of Pediatrics, Halmstad Hospital, Halmstad, Sweden. 6. Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden. 7. Section for Epidemiology and Social Medicine (EPSO), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 8. Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Abstract
BACKGROUND: Over the past 150 years, humans have become taller, and puberty has begun earlier. It is unclear if these changes are continuing in Sweden, and how longitudinal growth patterns are involved. We aimed to evaluate the underlying changes in growth patterns from birth to adulthood by QEPS estimates in two Swedish cohorts born in 1974 and 1990. METHODS: Growth characteristics of the longitudinal 1974 and 1990-birth cohorts (n = 4181) were compared using the QEPS model together with adult heights. RESULTS: There was more rapid fetal/infancy growth in girls/boys born in 1990 compared to 1974, as shown by a faster Etimescale and they were heavier at birth. The laterborn were taller also in childhood as shown by a higher Q-function. Girls born in 1990 had earlier and more pronounced growth during puberty than girls born in 1974. Individuals in the 1990 cohort attained greater adult heights than those in the 1974 cohort; 6 mm taller for females and 10 mm for males. CONCLUSION: A positive change in adult height was attributed to more growth during childhood in both sexes and during puberty for girls. The QEPS model proved to be effective detecting small changes of growth patterns, between two longitudinal growth cohorts born only 16 years apart.
BACKGROUND: Over the past 150 years, humans have become taller, and puberty has begun earlier. It is unclear if these changes are continuing in Sweden, and how longitudinal growth patterns are involved. We aimed to evaluate the underlying changes in growth patterns from birth to adulthood by QEPS estimates in two Swedish cohorts born in 1974 and 1990. METHODS: Growth characteristics of the longitudinal 1974 and 1990-birth cohorts (n = 4181) were compared using the QEPS model together with adult heights. RESULTS: There was more rapid fetal/infancy growth in girls/boys born in 1990 compared to 1974, as shown by a faster Etimescale and they were heavier at birth. The laterborn were taller also in childhood as shown by a higher Q-function. Girls born in 1990 had earlier and more pronounced growth during puberty than girls born in 1974. Individuals in the 1990 cohort attained greater adult heights than those in the 1974 cohort; 6 mm taller for females and 10 mm for males. CONCLUSION: A positive change in adult height was attributed to more growth during childhood in both sexes and during puberty for girls. The QEPS model proved to be effective detecting small changes of growth patterns, between two longitudinal growth cohorts born only 16 years apart.
Authors: Anton Holmgren; Aimon Niklasson; Andreas F M Nierop; Gary Butler; Kerstin Albertsson-Wikland Journal: Pediatr Res Date: 2021-11-03 Impact factor: 3.953
Authors: Kerstin Albertsson-Wikland; Aimon Niklasson; Anton Holmgren; Lars Gelander; Andreas F M Nierop Journal: Acta Paediatr Date: 2020-01-30 Impact factor: 2.299
Authors: Kerstin Albertsson-Wikland; Aimon Niklasson; Lars Gelander; Anton Holmgren; Andreas F M Nierop Journal: BMC Pediatr Date: 2021-11-13 Impact factor: 2.125
Authors: Li Chen; Binbin Su; Yi Zhang; Tao Ma; Jieyu Liu; Zhaogeng Yang; Yanhui Li; Di Gao; Manman Chen; Ying Ma; Xijie Wang; Bo Wen; Jun Jiang; Yanhui Dong; Yi Song; Jun Ma Journal: Front Endocrinol (Lausanne) Date: 2022-07-22 Impact factor: 6.055