Jun Sik Yoon1, Yu Rim Lee1, Young-Oh Kweon1, Won Young Tak1, Se Young Jang1, Soo Young Park1, Keun Hur2, Jung Gil Park3, Hye Won Lee4, Jae Min Chun5, Young Seok Han5, Won Kee Lee6. 1. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital. 2. Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University. 3. Department of Internal Medicine, College of Medicine, Yeungnam University. 4. Department of Pathology, Keimyung University School of Medicine. 5. Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital. 6. Department of Biostatistics, School of Medicine, Medical Research Collaboration Center in Kyungpook National University, Kyungpook National University, Daegu, South Korea.
Abstract
BACKGROUND: To compare the clinical value of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) for hepatocellular carcinoma (HCC) recurrence prediction after radiofrequency ablation (RFA) and to investigate other predictors of HCC recurrence. PATIENTS AND METHODS: Between 2011 and 2016, 130 patients with HCC who underwent ARFI elastography and TE within 6 months before curative RFA were prospectively enrolled. Independent predictors of HCC recurrence were analyzed separately using ARFI elastography and TE. ARFI elastography and TE accuracy to predict HCC recurrence was determined by receiver operating characteristic curve analysis. RESULTS: Of all included patients (91 men; mean age, 63.5 years; range: 43-84 years), 51 (42.5%) experienced HCC recurrence during the follow-up period (median, 21.9 months). In multivariable analysis using ARFI velocity, serum albumin and ARFI velocity [hazard ratios: 2.873; 95% confidence interval (CI): 1.806-4.571; P<0.001] were independent predictors of recurrence, and in multivariable analysis using TE value, serum albumin and TE value (hazard ratios: 1.028; 95% CI: 1.013-1.043; P<0.001) were independent predictors of recurrence. The area under the receiver operating characteristic curve of ARFI elastography (0.821; 95% CI: 0.747-0.895) was not statistically different from that of TE (0.793; 95% CI: 0.712-0.874) for predicting HCC recurrence (P=0.827). The optimal ARFI velocity and TE cutoff values were 1.6 m/s and 14 kPa, respectively. CONCLUSION: ARFI elastography and TE yield comparable predictors of HCC recurrence after RFA.
BACKGROUND: To compare the clinical value of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) for hepatocellular carcinoma (HCC) recurrence prediction after radiofrequency ablation (RFA) and to investigate other predictors of HCC recurrence. PATIENTS AND METHODS: Between 2011 and 2016, 130 patients with HCC who underwent ARFI elastography and TE within 6 months before curative RFA were prospectively enrolled. Independent predictors of HCC recurrence were analyzed separately using ARFI elastography and TE. ARFI elastography and TE accuracy to predict HCC recurrence was determined by receiver operating characteristic curve analysis. RESULTS: Of all included patients (91 men; mean age, 63.5 years; range: 43-84 years), 51 (42.5%) experienced HCC recurrence during the follow-up period (median, 21.9 months). In multivariable analysis using ARFI velocity, serum albumin and ARFI velocity [hazard ratios: 2.873; 95% confidence interval (CI): 1.806-4.571; P<0.001] were independent predictors of recurrence, and in multivariable analysis using TE value, serum albumin and TE value (hazard ratios: 1.028; 95% CI: 1.013-1.043; P<0.001) were independent predictors of recurrence. The area under the receiver operating characteristic curve of ARFI elastography (0.821; 95% CI: 0.747-0.895) was not statistically different from that of TE (0.793; 95% CI: 0.712-0.874) for predicting HCC recurrence (P=0.827). The optimal ARFI velocity and TE cutoff values were 1.6 m/s and 14 kPa, respectively. CONCLUSION: ARFI elastography and TE yield comparable predictors of HCC recurrence after RFA.
Authors: Song Wang; Jingtao Liu; Hao Wu; Anna Jiang; Kun Zhao; Kun Yan; Wei Wu; Haibo Han; Yanhua Zhang; Wei Yang Journal: Chin J Cancer Res Date: 2021-12-31 Impact factor: 5.087
Authors: Tae Hyung Kim; Jung Mi Chang; Soon Ho Um; Heejung Jee; Yoo Ra Lee; Han Ah Lee; Sun Young Yim; Na Yeon Han; Jae Min Lee; Hyuk Soon Choi; Eun Sun Kim; Young-Dong Yu; Bora Keum; Min Ju Kim; Hyunggin An; Beom Jin Park; Yeon Seok Seo; Dong-Sik Kim; Hyung Joon Yim; Sung Bum Cho; Yoon Tae Jeen; Hong Sik Lee; Hoon Jai Chun; Yun Hwan Kim; Chang Duck Kim Journal: Medicine (Baltimore) Date: 2019-06 Impact factor: 1.817