Haiping Duan1,2,3, Dongfeng Zhang1, Yajun Liang4, Chunsheng Xu1,2, Yili Wu1, Xiaocao Tian2, Zengchang Pang2, Qihua Tan5,6, Shuxia Li5, Chengxuan Qiu3. 1. Department of Epidemiology and Health Statistics, Qingdao University School of Public Health, Qingdao, Shandong, China. 2. Qingdao Center for Disease Control and Prevention, Qingdao, Shandong, China. 3. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden. 4. Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. 5. Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 6. Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Abstract
OBJECTIVES: The heritability of age-related hearing loss has been studied mostly in developed countries. The authors aimed to estimate the heritability of better ear hearing level (BEHL), defined as hearing level of the better ear at a given frequency, and pure-tone averages at the middle (0.5, 1.0, and 2.0 kHz) and high (4.0, 8.0, and 12.5 kHz) frequencies among middle-aged and elderly Chinese twins, and to explore their genetic correlations. DESIGN: This population-based twin study included 226 monozygotic and 132 dizygotic twin-pairs and 1 triplet (age range, 33 to 80 years; mean age, 51.55 years). Pure-tone air-conducted hearing thresholds in each ear were measured at the frequencies of 0.5, 1.0, 2.0, 4.0, 8.0, and 12.5 kHz with a diagnostic audiometer. Univariate and multivariate twin models were fitted to evaluate heritability and genetic correlations. RESULTS: Our data showed a reverse J-shaped pattern of BEHLs at six frequencies by age and sex. Univariate analysis showed that the heritability of BEHLs at the frequencies between 2.0 and 12.5 kHz ranged from 47.08 to 54.20%, but the heritability at the frequencies of 0.5 and 1.0 kHz was 1.65% and 18.68%, respectively. The heritability of pure-tone average at the middle and high frequencies was 34.77% and 43.26%, respectively. Multivariate analysis showed significant genetic correlations among BEHLs at all six frequencies, with the correlation coefficients ranging from 0.48 to 0.83 at middle frequencies, and from 0.46 to 0.75 at high frequencies. CONCLUSIONS: This population-based twin study suggests that genetic factors are associated with age-related hearing loss at middle and high frequencies among middle-aged and elderly Chinese.
OBJECTIVES: The heritability of age-related hearing loss has been studied mostly in developed countries. The authors aimed to estimate the heritability of better ear hearing level (BEHL), defined as hearing level of the better ear at a given frequency, and pure-tone averages at the middle (0.5, 1.0, and 2.0 kHz) and high (4.0, 8.0, and 12.5 kHz) frequencies among middle-aged and elderly Chinese twins, and to explore their genetic correlations. DESIGN: This population-based twin study included 226 monozygotic and 132 dizygotic twin-pairs and 1 triplet (age range, 33 to 80 years; mean age, 51.55 years). Pure-tone air-conducted hearing thresholds in each ear were measured at the frequencies of 0.5, 1.0, 2.0, 4.0, 8.0, and 12.5 kHz with a diagnostic audiometer. Univariate and multivariate twin models were fitted to evaluate heritability and genetic correlations. RESULTS: Our data showed a reverse J-shaped pattern of BEHLs at six frequencies by age and sex. Univariate analysis showed that the heritability of BEHLs at the frequencies between 2.0 and 12.5 kHz ranged from 47.08 to 54.20%, but the heritability at the frequencies of 0.5 and 1.0 kHz was 1.65% and 18.68%, respectively. The heritability of pure-tone average at the middle and high frequencies was 34.77% and 43.26%, respectively. Multivariate analysis showed significant genetic correlations among BEHLs at all six frequencies, with the correlation coefficients ranging from 0.48 to 0.83 at middle frequencies, and from 0.46 to 0.75 at high frequencies. CONCLUSIONS: This population-based twin study suggests that genetic factors are associated with age-related hearing loss at middle and high frequencies among middle-aged and elderly Chinese.
Authors: Sophie Boucher; Fabienne Wong Jun Tai; Sedigheh Delmaghani; Andrea Lelli; Amrit Singh-Estivalet; Typhaine Dupont; Magali Niasme-Grare; Vincent Michel; Nicolas Wolff; Amel Bahloul; Yosra Bouyacoub; Didier Bouccara; Bernard Fraysse; Olivier Deguine; Lionel Collet; Hung Thai-Van; Eugen Ionescu; Jean-Louis Kemeny; Fabrice Giraudet; Jean-Pierre Lavieille; Arnaud Devèze; Anne-Laure Roudevitch-Pujol; Christophe Vincent; Christian Renard; Valérie Franco-Vidal; Claire Thibult-Apt; Vincent Darrouzet; Eric Bizaguet; Arnaud Coez; Hugues Aschard; Nicolas Michalski; Gaëlle M Lefevre; Anne Aubois; Paul Avan; Crystel Bonnet; Christine Petit Journal: Proc Natl Acad Sci U S A Date: 2020-11-23 Impact factor: 11.205
Authors: Shadi Ahmadmehrabi; Binglan Li; Joseph Park; Batsal Devkota; Marijana Vujkovic; Yi-An Ko; David Van Wagoner; W H Wilson Tang; Ian Krantz; Marylyn Ritchie; Jason Brant; Michael J Ruckenstein; Douglas J Epstein; Daniel J Rader Journal: Hum Genet Date: 2021-03-21 Impact factor: 4.132
Authors: Samuel R Mathias; Emma E M Knowles; Josephine Mollon; Amanda L Rodrigue; Mary K Woolsey; Alyssa M Hernandez; Amy S Garrett; Peter T Fox; Rene L Olvera; Juan M Peralta; Satish Kumar; Harald H H Göring; Ravi Duggirala; Joanne E Curran; John Blangero; David C Glahn Journal: iScience Date: 2022-08-24
Authors: Stacey S Cherny; Gregory Livshits; Helena R R Wells; Maxim B Freidin; Ida Malkin; Sally J Dawson; Frances M K Williams Journal: Eur J Hum Genet Date: 2020-03-20 Impact factor: 5.351