Literature DB >> 29793722

Understanding and Treating Chiari-like Malformation and Syringomyelia in Dogs.

Ashley C Hechler1, Sarah A Moore2.   

Abstract

Chiari-like malformation (CM) and syringomyelia (SM) are common and debilitating conditions in toy and small breed dogs. CM, considered ubiquitous in the cavalier King Charles spaniel (CKCS) population, results in abnormal cerebrospinal fluid dynamics which can lead to the development of SM. The clinical signs associated with CM/SM are frequently confused with other otologic and dermatologic conditions, which may delay appropriate treatment. A definitive diagnosis of CM/SM requires advanced imaging; however, due to expense associated with this, many cases are managed presumptively and symptomatically for the condition. The primary goal of treatment is to manage neuropathic pain and neurologic deficits through pharmaceutical or surgical approaches. Current literature suggests that most CM/SM-affected dogs have progression of their clinical signs in spite of medical or surgical management; however, most maintain a good quality of life based on owner assessments. Lack of correlation between structural markers of disease and clinician and owner-derived measures of neuropathic pain highlight the need for more robust, quantitative measures of pain in this common veterinary disease.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cavalier King Charles Spaniel; Chiari-like malformation; medical management; neuropathic pain; surgical decompression; syringomyelia

Mesh:

Year:  2018        PMID: 29793722     DOI: 10.1053/j.tcam.2018.03.002

Source DB:  PubMed          Journal:  Top Companion Anim Med        ISSN: 1946-9837


  4 in total

1.  Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels.

Authors:  Courtney R Sparks; Ian Robertson; Natasha J Olby
Journal:  J Vet Intern Med       Date:  2019-02-13       Impact factor: 3.333

2.  Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia.

Authors:  Courtney R Sparks; Christian Woelfel; Ian Robertson; Natasha J Olby
Journal:  J Vet Intern Med       Date:  2021-01-11       Impact factor: 3.175

Review 3.  Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment.

Authors:  Samantha L Eaton; Fraser Murdoch; Nina M Rzechorzek; Gerard Thompson; Claudia Hartley; Benjamin Thomas Blacklock; Chris Proudfoot; Simon G Lillico; Peter Tennant; Adrian Ritchie; James Nixon; Paul M Brennan; Stefano Guido; Nadia L Mitchell; David N Palmer; C Bruce A Whitelaw; Jonathan D Cooper; Thomas M Wishart
Journal:  Cells       Date:  2022-08-25       Impact factor: 7.666

4.  Ventriculomegaly in Cavalier King Charles Spaniels with Chiari-like malformation: relationship with clinical and imaging findings.

Authors:  Federica Tirrito; Francesca Cozzi; Martina Bonaldi; Stefania Corazzo; Barbara Contiero; Rocco Lombardo
Journal:  J Vet Med Sci       Date:  2022-07-12       Impact factor: 1.105

  4 in total

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