Literature DB >> 29793621

Cooling the Itch via TRPM8.

Boyi Liu1, Sven-Eric Jordt2.   

Abstract

Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29793621      PMCID： PMC6301073          DOI： 10.1016/j.jid.2018.01.020

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  12 in total

1.  IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Authors:  Boyi Liu; Yan Tai; Satyanarayana Achanta; Melanie M Kaelberer; Ana I Caceres; Xiaomei Shao; Jianqiao Fang; Sven-Eric Jordt
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-07       Impact factor: 11.205

2.  The effects of thermal stimulation on clinical and experimental itch.

Authors:  Heinrich Fruhstorfer; Maren Hermanns; Lothar Latzke
Journal:  Pain       Date:  1986-02       Impact factor: 6.961

3.  Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Authors:  Ana I Caceres; Boyi Liu; Sairam V Jabba; Satyanarayana Achanta; John B Morris; Sven-Eric Jordt
Journal:  Br J Pharmacol       Date:  2017-03-23       Impact factor: 8.739

4.  Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.

Authors:  Radhika Palkar; Serra Ongun; Edward Catich; Natalie Li; Neil Borad; Angela Sarkisian; David D McKemy
Journal:  J Invest Dermatol       Date:  2017-12-27       Impact factor: 8.551

5.  TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.

Authors:  Boyi Liu; Lu Fan; Shrilatha Balakrishna; Aiwei Sui; John B Morris; Sven-Eric Jordt
Journal:  Pain       Date:  2013-06-29       Impact factor: 6.961

6.  Novel TRPM8 agonist cooling compound against chronic itch: results from a randomized, double-blind, controlled, pilot study in dry skin.

Authors:  S Ständer; M Augustin; D Roggenkamp; C Blome; T Heitkemper; A C Worthmann; G Neufang
Journal:  J Eur Acad Dermatol Venereol       Date:  2016-12-07       Impact factor: 6.166

Review 7.  Peripheral Mechanisms of Itch.

Authors:  Ehsan Azimi; Jimmy Xia; Ethan A Lerner
Journal:  Curr Probl Dermatol       Date:  2016-08-23

8.  The menthol receptor TRPM8 is the principal detector of environmental cold.

Authors:  Diana M Bautista; Jan Siemens; Joshua M Glazer; Pamela R Tsuruda; Allan I Basbaum; Cheryl L Stucky; Sven-Eric Jordt; David Julius
Journal:  Nature       Date:  2007-05-30       Impact factor: 49.962

Review 9.  Why we scratch an itch: the molecules, cells and circuits of itch.

Authors:  Diana M Bautista; Sarah R Wilson; Mark A Hoon
Journal:  Nat Neurosci       Date:  2014-01-28       Impact factor: 24.884

10.  Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.

Authors:  Adam P Kardon; Erika Polgár; Junichi Hachisuka; Lindsey M Snyder; Darren Cameron; Sinead Savage; Xiaoyun Cai; Sergei Karnup; Christopher R Fan; Gregory M Hemenway; Carcha S Bernard; Erica S Schwartz; Hiroshi Nagase; Christoph Schwarzer; Masahiko Watanabe; Takahiro Furuta; Takeshi Kaneko; H Richard Koerber; Andrew J Todd; Sarah E Ross
Journal:  Neuron       Date:  2014-04-10       Impact factor: 17.173
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  8 in total

1.  Drosophila menthol sensitivity and the Precambrian origins of transient receptor potential-dependent chemosensation.

Authors:  Nathaniel J Himmel; Jamin M Letcher; Akira Sakurai; Thomas R Gray; Maggie N Benson; Daniel N Cox
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-09-23       Impact factor: 6.237

2.  Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis.

Authors:  Chengyu Yin; Boyu Liu; Ping Wang; Xiaojie Li; Yuanyuan Li; Xiaoli Zheng; Yan Tai; Chuan Wang; Boyi Liu
Journal:  Br J Pharmacol       Date:  2020-02-12       Impact factor: 8.739

3.  Interventions for chronic pruritus of unknown origin.

Authors:  Andrea Andrade; Chii Yang Kuah; Juliana Esther Martin-Lopez; Shunjie Chua; Volha Shpadaruk; Gloria Sanclemente; Juan Va Franco
Journal:  Cochrane Database Syst Rev       Date:  2020-01-25

4.  ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.

Authors:  Xiaoli Zheng; Yan Tai; Dongwei He; Boyu Liu; Chuan Wang; Xiaomei Shao; Sven-Eric Jordt; Boyi Liu
Journal:  Mol Pain       Date:  2019 Jan-Dec       Impact factor: 3.395

5.  Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.

Authors:  Boyi Liu; Yan Tai; Boyu Liu; Ana I Caceres; Chengyu Yin; Sven-Eric Jordt
Journal:  JCI Insight       Date:  2019-06-11

6.  Exploring neuronal mechanisms involved in the scratching behavior of a mouse model of allergic contact dermatitis by transcriptomics.

Authors:  Boyu Liu; Ruixiang Chen; Jie Wang; Yuanyuan Li; Chengyu Yin; Yan Tai; Huimin Nie; Danyi Zeng; Junfan Fang; Junying Du; Yi Liang; Xiaomei Shao; Jianqiao Fang; Boyi Liu
Journal:  Cell Mol Biol Lett       Date:  2022-02-19       Impact factor: 5.787

Review 7.  TRP Channels as Drug Targets to Relieve Itch.

Authors:  Zili Xie; Hongzhen Hu
Journal:  Pharmaceuticals (Basel)       Date:  2018-10-06

8.  IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain.

Authors:  Chengyu Yin; Boyu Liu; Yuanyuan Li; Xiaojie Li; Jie Wang; Ruixiang Chen; Yan Tai; Qiyang Shou; Ping Wang; Xiaomei Shao; Yi Liang; Hong Zhou; Wenli Mi; Jianqiao Fang; Boyi Liu
Journal:  Theranostics       Date:  2020-10-27       Impact factor: 11.556
  8 in total

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