Literature DB >> 29791863

Role of GW182 protein in the cell.

Saife Niaz1, Mahboob Ul Hussain2.   

Abstract

GW182 proteins interact directly with the argonaute proteins and constitute key components of miRNA repressor complexes (miRISC) in metazoans. As argonautes are insufficient for silencing they recruit the GW182 s that act as scaffold proteins inducing downstream translational repression, target mRNA deadenylation and exonucleolytic mRNA degradation. Besides their role as part of repressor complexes inside the cell, they function in wide variety of cellular processes as highlighted in this review. The present review summarises and discusses in detail our current knowledge of the GW182 s and their role inside the cell.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Ago; GW182; TNRC6; miRISC; miRNA

Mesh：

Substances：

Year:  2018        PMID： 29791863     DOI： 10.1016/j.biocel.2018.05.009

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  7 in total

1.  Argonaute1 and Gawky Are Required for the Development and Reproduction of Melon fly, Zeugodacus cucurbitae.

Authors:  Momana Jamil; Shakil Ahmad; Yingqiao Ran; Siya Ma; Fengqin Cao; Xianwu Lin; Rihui Yan
Journal:  Front Genet       Date:  2022-06-23       Impact factor: 4.772

2.  Gawky modulates MTF-1-mediated transcription activation and metal discrimination.

Authors:  Ruirui Jia; Zhenxing Song; Jiamei Lin; Zhengguo Li; Ge Shan; Chuan Huang
Journal:  Nucleic Acids Res       Date:  2021-06-21       Impact factor: 16.971

Review 3.  The Influence of Host miRNA Binding to RNA Within RNA Viruses on Virus Multiplication.

Authors:  Lin Lei; Anchun Cheng; Mingshu Wang; Renyong Jia
Journal:  Front Cell Infect Microbiol       Date:  2022-04-21       Impact factor: 6.073

4.  Defining an evolutionarily conserved role of GW182 in circular RNA degradation.

Authors:  Ruirui Jia; Mei-Sheng Xiao; Zhengguo Li; Ge Shan; Chuan Huang
Journal:  Cell Discov       Date:  2019-09-17       Impact factor: 10.849

5.  Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.

Authors:  Fusako Munakata; Masataka Suzawa; Kumiko Ui-Tei
Journal:  Genes (Basel)       Date:  2021-02-13       Impact factor: 4.096

6.  Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

Authors:  Zhongtian Liu; Samantha T Johnson; Zhiying Zhang; David R Corey
Journal:  Nucleic Acid Ther       Date:  2019-10-31       Impact factor: 5.486

7.  Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

Authors:  Samantha T Johnson; Yongjun Chu; Jing Liu; David R Corey
Journal:  RNA       Date:  2021-06-09       Impact factor: 4.942
  7 in total

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