Shivering following cardiac surgery: hemodynamic changes and reversal.

The effects of shivering on hemodynamics and systemic oxygenation, as well as the effectiveness of therapeutic interventions in decreasing shivering and increasing mixed venous oxygen saturation, were studied. Thirty adult patients undergoing cardiopulmonary bypass with systemic hypothermia were observed for 1 1/2 to 5 hours postoperatively for signs of shivering associated with a simultaneous decrease in oxygen transport. Systemic and pulmonary hemodynamic measurements were made, blood temperature and mixed venous oxygen saturation were monitored via the pulmonary arterial catheter, and oxygen consumption and delivery were calculated. Shivering was graded by a single investigator on scale of 0 to 4, with 0 = no shivering and 4 = continuous violent muscle activity. Therapy was instituted when shivering reached grade 4 or when SvO2 decreased to less than two thirds of its value on arrival in the intensive care unit (ICU). Patients were randomly assigned to receive either morphine sulfate, 5 to 10 mg, or meperidine, 25 to 50 mg intravenously (IV), followed by the other narcotic if the initial drug failed to improve SvO2 or decrease shivering within ten minutes. The end-point for successful treatment was a return of SvO2 to within 5% to 10% of its value upon arrival in the ICU or a cessation of shivering that did not recur within 45 minutes. Twenty of the thirty patients shivered sufficiently to decrease SvO2 by more than one third of its initial value, thus requiring pharmacologic therapy. As shivering increased from a score of 0.8 +/- 1.1 to 3.4 +/- 0.9, SvO2 decreased from 74 +/- 6% to 57 +/- 12%.(ABSTRACT TRUNCATED AT 250 WORDS)

RCT Entities:   Population Interventions Outcomes