Literature DB >> 29790026

Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study.

M Y Zenko1, K A Baranova1, E A Rybnikova2.   

Abstract

In the rat experimental model of posttraumatic stress disorder (PTSD), the level of blood corticosterone was at least eight-fold increased (an overrelease). The use of hypobaric hypoxic preconditioning or short-term inhibition of glucocorticoid synthesis by metyrapone injection prevented development of the experimental PTSD.

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Year:  2018        PMID： 29790026     DOI： 10.1134/S0012496618020059

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  7 in total

1.  Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model.

Authors:  Samantha M Keller; William B Schreiber; Briana R Stanfield; Dayan Knox
Journal:  Behav Brain Res       Date:  2015-03-31       Impact factor: 3.332

Review 2.  Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis.

Authors:  Marie-Louise Meewisse; Johannes B Reitsma; Giel-Jan de Vries; Berthold P R Gersons; Miranda Olff
Journal:  Br J Psychiatry       Date:  2007-11       Impact factor: 9.319

Review 3.  Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review.

Authors:  William Berger; Mauro V Mendlowicz; Carla Marques-Portella; Gustavo Kinrys; Leonardo F Fontenelle; Charles R Marmar; Ivan Figueira
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2008-12-24       Impact factor: 5.067

4.  Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory.

Authors:  B Roozendaal; B Bohus; J L McGaugh
Journal:  Psychoneuroendocrinology       Date:  1996-11       Impact factor: 4.905

Review 5.  Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder.

Authors:  R Yehuda; E L Giller; S M Southwick; M T Lowy; J W Mason
Journal:  Biol Psychiatry       Date:  1991-11-15       Impact factor: 13.382

6.  Stress-restress: effects on ACTH and fast feedback.

Authors:  I Liberzon; M Krstov; E A Young
Journal:  Psychoneuroendocrinology       Date:  1997-08       Impact factor: 4.905

7.  Stable modifications to the expression of neurohormones in the rat hypothalamus in a model of post-traumatic stress disorder.

Authors:  V I Mironova; E A Rybnikova
Journal:  Neurosci Behav Physiol       Date:  2009-12-11
  7 in total

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