Stephen Mason1, Rose Kingston2, Lucy Shneyer3, Máiréad Harding2. 1. Oral Care Medical Affairs, Research and Development, GSK Consumer Healthcare, Weybridge, Surrey, UK. 2. Oral Health Services Research Centre, Cork University Dental School and Hospital, Wilton, Cork, Ireland. 3. Shneyer Statistics LLC, Denville, NJ, USA.
Abstract
OBJECTIVES/AIMS: To evaluate continuous and episodic twice-daily usage regimens of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (CSPS). MATERIALS AND METHODS: In this exploratory, single-centre, randomised, examiner-blind study, subjects with dentinal hypersensitivity were randomised to continuous (24 weeks) use of a 5% CSPS-containing dentifrice or episodic use of the dentifrice comprising two 8-week treatment periods separated by 8 weeks' use of a standard fluoride dentifrice. Sensitivity was assessed by tactile threshold (Yeaple probe) and evaporative (air) sensitivity (Schiff sensitivity score). Other measures included labelled magnitude scales to assess subjects' responses to the evaporative stimulus, the Dentine Hypersensitivity Experience Questionnaire and a tooth sensitivity question. RESULTS: Seventy-six subjects were randomised to continuous (n=38) or episodic (n=38) use. Small but statistically significant improvements from baseline in Schiff sensitivity scores were observed at weeks 8, 16 and 24 with both regimens (all P<0.05). Increases from baseline in tactile threshold were not statistically significant. No significant between-regimen difference was observed for any endpoint. No treatment-related adverse events were reported. DISCUSSION: Dentifrice containing 5% CSPS improved dentinal hypersensitivity with both episodic and continuous twice-daily usage regimens over 24 weeks and was well tolerated. CONCLUSION: No performance differences were observed between the two usage regimens.
OBJECTIVES/AIMS: To evaluate continuous and episodic twice-daily usage regimens of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (CSPS). MATERIALS AND METHODS: In this exploratory, single-centre, randomised, examiner-blind study, subjects with dentinal hypersensitivity were randomised to continuous (24 weeks) use of a 5% CSPS-containing dentifrice or episodic use of the dentifrice comprising two 8-week treatment periods separated by 8 weeks' use of a standard fluoride dentifrice. Sensitivity was assessed by tactile threshold (Yeaple probe) and evaporative (air) sensitivity (Schiff sensitivity score). Other measures included labelled magnitude scales to assess subjects' responses to the evaporative stimulus, the Dentine Hypersensitivity Experience Questionnaire and a tooth sensitivity question. RESULTS: Seventy-six subjects were randomised to continuous (n=38) or episodic (n=38) use. Small but statistically significant improvements from baseline in Schiff sensitivity scores were observed at weeks 8, 16 and 24 with both regimens (all P<0.05). Increases from baseline in tactile threshold were not statistically significant. No significant between-regimen difference was observed for any endpoint. No treatment-related adverse events were reported. DISCUSSION: Dentifrice containing 5% CSPS improved dentinal hypersensitivity with both episodic and continuous twice-daily usage regimens over 24 weeks and was well tolerated. CONCLUSION: No performance differences were observed between the two usage regimens.
Authors: Quan Du Min; Zhuan Bian; Han Jiang; David C Greenspan; Anora K Burwell; Jipin Zhong; Bao Jun Tai Journal: Am J Dent Date: 2008-08 Impact factor: 1.522
Authors: Sarah R Baker; Barry J Gibson; Farzana Sufi; Ashley Barlow; Peter G Robinson Journal: J Clin Periodontol Date: 2013-11-06 Impact factor: 8.728