OBJECTIVE: To investigate the utility of intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) derived parameters in hypothalamus for monitoring the effect of Exendin-4 (Ex-4) intervention on the feeding behavior in obese diabetic rats within early feeding. METHODS: 21 obese and 19 non-obese rats which were treated with streptozotocin injections were initially divided into an obese diabetes group (OD, n = 10), a non-obese diabetes group (D, n = 8), an obese group (O, n = 9) and a non-obese group (N, n = 9). Then, the rats in the 4 groups received subcutaneous injections of Ex-4, and feeding behavior was examined at 5, 35, 65, 95, and 125 min. The hypothalamic function was evaluated by IVIM-DWI. Finally, the relationship between the hypothalamic function and the amount of food intake was analyzed. RESULTS: In comparison with the N group, the food intake significantly decreased in the O , OD, and D groups in response to Ex-4. Furthermore, a significant positive correlation was found between food intake and D values at different times from 5 to 125 min after Ex-4 intervention in all 4 groups. CONCLUSION: A direct correlation between the change of hypothalamic function and feeding behavior was detected in OD rats with Ex-4 intervention in the early feeding period. The hypothalamic D value derived from IVIM-DWI is promising to reflect the dynamic change of hypothalamic function due to intervention.
OBJECTIVE: To investigate the utility of intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) derived parameters in hypothalamus for monitoring the effect of Exendin-4 (Ex-4) intervention on the feeding behavior in obese diabeticrats within early feeding. METHODS: 21 obese and 19 non-obeserats which were treated with streptozotocin injections were initially divided into an obese diabetes group (OD, n = 10), a non-obese diabetes group (D, n = 8), an obese group (O, n = 9) and a non-obese group (N, n = 9). Then, the rats in the 4 groups received subcutaneous injections of Ex-4, and feeding behavior was examined at 5, 35, 65, 95, and 125 min. The hypothalamic function was evaluated by IVIM-DWI. Finally, the relationship between the hypothalamic function and the amount of food intake was analyzed. RESULTS: In comparison with the N group, the food intake significantly decreased in the O , OD, and D groups in response to Ex-4. Furthermore, a significant positive correlation was found between food intake and D values at different times from 5 to 125 min after Ex-4 intervention in all 4 groups. CONCLUSION: A direct correlation between the change of hypothalamic function and feeding behavior was detected in OD rats with Ex-4 intervention in the early feeding period. The hypothalamic D value derived from IVIM-DWI is promising to reflect the dynamic change of hypothalamic function due to intervention.
Authors: Timur H Kuru; Matthias C Roethke; Bram Stieltjes; Klaus Maier-Hein; Heinz-Peter Schlemmer; Boris A Hadaschik; Michael Fenchel Journal: J Comput Assist Tomogr Date: 2014 Jul-Aug Impact factor: 1.826
Authors: Simon Veedfald; Astrid Plamboeck; Carolyn F Deacon; Bolette Hartmann; Filip K Knop; Tina Vilsbøll; Jens J Holst Journal: Am J Physiol Gastrointest Liver Physiol Date: 2015-10-22 Impact factor: 4.052
Authors: Anthony P Goldstone; Christina G Prechtl; Samantha Scholtz; Alexander D Miras; Navpreet Chhina; Giuliana Durighel; Seyedeh S Deliran; Christian Beckmann; Mohammad A Ghatei; Damien R Ashby; Adam D Waldman; Bruce D Gaylinn; Michael O Thorner; Gary S Frost; Stephen R Bloom; Jimmy D Bell Journal: Am J Clin Nutr Date: 2014-04-23 Impact factor: 7.045