Ann M Vuong1, Joseph M Braun2, Glenys M Webster3, R Thomas Zoeller4, Andrew N Hoofnagle5, Andreas Sjödin6, Kimberly Yolton7, Bruce P Lanphear3, Aimin Chen8. 1. Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati 45267, OH, USA. 2. Department of Epidemiology, Brown University School of Public Health, 121 South Main St, Box G-S121-2, Providence 02912, RI, USA. 3. BC Children's Hospital Research Institute and Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby V5A 1S6, BC, Canada. 4. Department of Biology, University of Massachusetts Amherst, 611 North Pleasant St, Amherst 01003, MA, USA. 5. Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, NW120, Seattle 98195, WA, USA. 6. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mail Stop F-20, 4770 Buford Highway NE, Atlanta 30341, GA, USA. 7. Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7035, Cincinnati 45229, OH, USA. 8. Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati 45267, OH, USA. Electronic address: aimin.chen@uc.edu.
Abstract
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood. METHODS: We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years. RESULTS: Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years. A 10-fold increase in prenatal ∑PBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI -40.8%, -11.3%) in TSH. A ten-fold increase in prenatal ∑PBDEs was associated with a 0.25 pg/mL (0.07, 0.43) increase in free triiodothyronine (FT3). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T4 (FT4) in males. Prenatal ∑PBDEs were not associated with TT4, FT4, or total T3. CONCLUSIONS: These findings suggest an inverse relationship between prenatal ∑PBDEs and TSH at 3 years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males.
BACKGROUND:Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood. METHODS: We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years. RESULTS: Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years. A 10-fold increase in prenatal ∑PBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI -40.8%, -11.3%) in TSH. A ten-fold increase in prenatal ∑PBDEs was associated with a 0.25 pg/mL (0.07, 0.43) increase in free triiodothyronine (FT3). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T4 (FT4) in males. Prenatal ∑PBDEs were not associated with TT4, FT4, or total T3. CONCLUSIONS: These findings suggest an inverse relationship between prenatal ∑PBDEs and TSH at 3 years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males.
Authors: Joseph M Braun; Kimberly Yolton; Shaina L Stacy; Bahar Erar; George D Papandonatos; David C Bellinger; Bruce P Lanphear; Aimin Chen Journal: Neurotoxicology Date: 2017-07-20 Impact factor: 4.294
Authors: Mary R Arkoosh; Ahna L Van Gaest; Stacy A Strickland; Greg P Hutchinson; Alex B Krupkin; Joseph P Dietrich Journal: Chemosphere Date: 2016-12-08 Impact factor: 7.086
Authors: D L Phillips; J L Pirkle; V W Burse; J T Bernert; L O Henderson; L L Needham Journal: Arch Environ Contam Toxicol Date: 1989 Jul-Aug Impact factor: 2.804
Authors: David T Szabo; Vicki M Richardson; David G Ross; Janet J Diliberto; Prasada R S Kodavanti; Linda S Birnbaum Journal: Toxicol Sci Date: 2008-10-31 Impact factor: 4.849
Authors: Aimin Chen; Kimberly Yolton; Stephen A Rauch; Glenys M Webster; Richard Hornung; Andreas Sjödin; Kim N Dietrich; Bruce P Lanphear Journal: Environ Health Perspect Date: 2014-05-28 Impact factor: 9.031
Authors: Whitney J Cowell; Andreas Sjödin; Richard Jones; Ya Wang; Shuang Wang; Robin M Whyatt; Pam Factor-Litvak; Gary Bradwin; Abeer Hassoun; Sharon Oberfield; Julie B Herbstman Journal: Thyroid Date: 2019-05 Impact factor: 6.568
Authors: Huang Huang; Andreas Sjodin; Yingtai Chen; Xin Ni; Shuangge Ma; Herbert Yu; Mary H Ward; Robert Udelsman; Jennifer Rusiecki; Yawei Zhang Journal: Am J Epidemiol Date: 2020-02-28 Impact factor: 4.897
Authors: Marília Cristina Oliveira Souza; Paula Pícoli Devóz; João Paulo Bianchi Ximenez; Mariana Zuccherato Bocato; Bruno Alves Rocha; Fernando Barbosa Journal: Int J Environ Res Public Health Date: 2022-09-05 Impact factor: 4.614
Authors: June K Dunnick; Keith R Shockley; Daniel L Morgan; Gregory S Travlos; Kevin Gerrish; Thai-Vu T Ton; Ralph Wilson; Sukhdev S Brar; Amy E Brix; Suramya Waidyanatha; Esra Mutlu; Arun Kumar R Pandiri Journal: Toxicol Pathol Date: 2019-12-12 Impact factor: 1.930