Karn Wijarnpreecha1, Charat Thongprayoon1, Boonphiphop Boonpheng2, Panadeekarn Panjawatanan3, Konika Sharma1, Patompong Ungprasert4, Surakit Pungpapong5, Wisit Cheungpasitporn6. 1. Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York. 2. Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee. 3. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai. 4. Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok. 5. Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida. 6. Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Abstract
BACKGROUND/ OBJECTIVES: The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. METHODS: Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95% confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95% CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabetic patients [pooled OR 1.28 (95% CI: 0.94-1.75)]. CONCLUSION: A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.
BACKGROUND/ OBJECTIVES: The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. METHODS: Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95% confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95% CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabeticpatients [pooled OR 1.28 (95% CI: 0.94-1.75)]. CONCLUSION: A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.
Authors: Manuela Abbate; Catalina M Mascaró; Sofía Montemayor; María Barbería-Latasa; Miguel Casares; Cristina Gómez; Escarlata Angullo-Martinez; Silvia Tejada; Itziar Abete; Maria Angeles Zulet; Antoni Sureda; J Alfredo Martínez; Josep A Tur Journal: Nutrients Date: 2021-02-15 Impact factor: 5.717