John M Violanti1, Desta Fekedulegn, Michael E Andrew, Luenda E Charles, Ja K Gu, Diane B Miller. 1. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, the State University of New York, Buffalo, New York (Dr Violanti); Biostatistics and Epidemiology Branch (Dr Fekedulegn, Dr Andrew, Dr Charles, and Mr Gu); Toxicology and Molecular Biology Branch (Dr Miller), Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.
Abstract
OBJECTIVE: To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a 7-year period. METHODS: Baseline CAR was obtained from four saliva samples taken 15 minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD%Follow-up-FMD%Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend. RESULTS: Officers (n = 172; 81% men) had a mean ± SD age of 41 ± 7.6 years. Men in the lowest AUCI tertile (ie, atypical waking cortisol pattern) had a significantly larger 7-year mean decline in FMD% (mean ± SE: -2.56 ± 0.64) compared with men in the highest tertile (-0.89 ± 0.69) (P = 0.0087). CONCLUSIONS: An awakening cortisol AUCI predicted worsening of FMD% approximately 7 years later among male officers.
OBJECTIVE: To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a 7-year period. METHODS: Baseline CAR was obtained from four saliva samples taken 15 minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD%Follow-up-FMD%Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend. RESULTS: Officers (n = 172; 81% men) had a mean ± SD age of 41 ± 7.6 years. Men in the lowest AUCI tertile (ie, atypical waking cortisol pattern) had a significantly larger 7-year mean decline in FMD% (mean ± SE: -2.56 ± 0.64) compared with men in the highest tertile (-0.89 ± 0.69) (P = 0.0087). CONCLUSIONS: An awakening cortisol AUCI predicted worsening of FMD% approximately 7 years later among male officers.
Authors: Rahel R Looser; Petra Metzenthin; Susanne Helfricht; Brigitte M Kudielka; Adrian Loerbroks; Julian F Thayer; Joachim E Fischer Journal: Psychosom Med Date: 2010-02-26 Impact factor: 4.312
Authors: Parveen Nedra Joseph; John M Violanti; Richard Donahue; Michael E Andrew; Maurizio Trevisan; Cecil M Burchfiel; Joan Dorn Journal: J Occup Environ Med Date: 2010-10 Impact factor: 2.162