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Literature DB >> 29787286

Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels-Alder Strategy.

Abstract

A concise total synthesis of the neoclerodane diterpene salvinorin A from 3-furaldehyde is reported using two highly diastereoselective intramolecular Diels-Alder reactions (IMDA) as the key transformations.

Entities: Chemical

Year: 2018 PMID： 29787286 DOI： 10.1021/acs.orglett.8b01357

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

4 in total

Review 1. Chemical syntheses of the salvinorin chemotype of KOR agonist.

Authors: Sarah J Hill; Aurélien U C M Brion; Ryan A Shenvi
Journal: Nat Prod Rep Date: 2020-11-18 Impact factor: 13.423

Review 2. Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects.

Authors: Andreia Machado Brito-da-Costa; Diana Dias-da-Silva; Nelson G M Gomes; Ricardo Jorge Dinis-Oliveira; Áurea Madureira-Carvalho
Journal: Pharmaceuticals (Basel) Date: 2021-02-03

3. Formal Total Synthesis of Salvinorin A.

Authors: Marc Halang; Martin E Maier
Journal: ChemistryOpen Date: 2022-02-26 Impact factor: 2.630

Review 4. Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide.

Authors: Soumen Chakraborty; Susruta Majumdar
Journal: Biochemistry Date: 2020-09-22 Impact factor: 3.162

4 in total