Maria Nelander1, Daniel Hannsberger2, Inger Sundström-Poromaa1, Lina Bergman1,3, Jan Weis2,4, Helena Åkerud1,5, Johan Wikström2, Anna-Karin Wikström1. 1. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. 2. Department of Radiology, Uppsala University, Uppsala, Sweden. 3. Center for Clinical Research Dalarna, Falun, Sweden. 4. Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden. 5. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Abstract
INTRODUCTION: Cerebral complications are the main reasons for morbidity and mortality in preeclampsia and eclampsia. As yet, we do not know whether the pathophysiology entails hypo- or hyperperfusion of the brain, or how and when edema emerges, due to the difficulty of examining the cerebral circulation. MATERIAL AND METHODS: We have used a non-invasive diffusion weighted-magnetic resonance imaging technique, intravoxel incoherent motion, to study cerebral perfusion on the capillary level and cerebral edema in women with preeclampsia (n = 30), normal pregnancy (n = 32), and non-pregnant women (n = 16). Estimates of cerebral blood volume, blood flow, and edema were measured in 5 different regions. These points were chosen to represent blood supply areas of both the carotid and vertebrobasilar arteries, and to include both white and gray matter. RESULTS: Except for the caudate nucleus, we did not detect any differences in cerebral perfusion measures on a group level. In the caudate nucleus, we found lower cerebral blood volume and lower blood flow in preeclampsia than in either normal pregnancy (P = .01 and P = .03, respectively) or non-pregnant women (both P = .02). No differences in edema were detected between study groups. CONCLUSION: The cerebral perfusion measures were comparable between the study groups, except for a portion of the basal ganglia where hypoperfusion was detected in preeclampsia but not in normal pregnancy or non-pregnant women.
INTRODUCTION: Cerebral complications are the main reasons for morbidity and mortality in preeclampsia and eclampsia. As yet, we do not know whether the pathophysiology entails hypo- or hyperperfusion of the brain, or how and when edema emerges, due to the difficulty of examining the cerebral circulation. MATERIAL AND METHODS: We have used a non-invasive diffusion weighted-magnetic resonance imaging technique, intravoxel incoherent motion, to study cerebral perfusion on the capillary level and cerebral edema in women with preeclampsia (n = 30), normal pregnancy (n = 32), and non-pregnant women (n = 16). Estimates of cerebral blood volume, blood flow, and edema were measured in 5 different regions. These points were chosen to represent blood supply areas of both the carotid and vertebrobasilar arteries, and to include both white and gray matter. RESULTS: Except for the caudate nucleus, we did not detect any differences in cerebral perfusion measures on a group level. In the caudate nucleus, we found lower cerebral blood volume and lower blood flow in preeclampsia than in either normal pregnancy (P = .01 and P = .03, respectively) or non-pregnant women (both P = .02). No differences in edema were detected between study groups. CONCLUSION: The cerebral perfusion measures were comparable between the study groups, except for a portion of the basal ganglia where hypoperfusion was detected in preeclampsia but not in normal pregnancy or non-pregnant women.
Authors: Lina Bergman; Pablo Torres-Vergara; Jeffrey Penny; Johan Wikström; Maria Nelander; Jose Leon; Mary Tolcher; James M Roberts; Anna-Karin Wikström; Carlos Escudero Journal: Curr Hypertens Rep Date: 2019-08-02 Impact factor: 5.369
Authors: Therese Friis; Anna-Karin Wikström; Jesenia Acurio; José León; Henrik Zetterberg; Kaj Blennow; Maria Nelander; Helena Åkerud; Helena Kaihola; Catherine Cluver; Felipe Troncoso; Pablo Torres-Vergara; Carlos Escudero; Lina Bergman Journal: Cells Date: 2022-02-24 Impact factor: 6.600