Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.

Literature DB >> 29786085

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.

Nina Dedic¹, Claudia Kühne¹, Mira Jakovcevski¹, Jakob Hartmann^1,2, Andreas J Genewsky¹, Karina S Gomes^1,3, Elmira Anderzhanova¹, Max L Pöhlmann¹, Simon Chang¹, Adam Kolarz¹, Annette M Vogl¹, Julien Dine¹, Michael W Metzger¹, Bianca Schmid¹, Rafael C Almada¹, Kerry J Ressler², Carsten T Wotjak¹, Valery Grinevich⁴, Alon Chen¹, Mathias V Schmidt¹, Wolfgang Wurst^5,6,7, Damian Refojo^1,8, Jan M Deussing⁹.

Abstract

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2018 PMID： 29786085 PMCID： PMC6951443 DOI： 10.1038/s41593-018-0151-z

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

50 in total

Review 1. Untangling GABAergic wiring in the cortical microcircuit.

Authors: Yoshiyuki Kubota
Journal: Curr Opin Neurobiol Date: 2013-11-16 Impact factor: 6.627

2. Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.

Authors: J Hartmann; N Dedic; M L Pöhlmann; A Häusl; H Karst; C Engelhardt; S Westerholz; K V Wagner; C Labermaier; L Hoeijmakers; M Kertokarijo; A Chen; M Joëls; J M Deussing; M V Schmidt
Journal: Mol Psychiatry Date: 2016-05-31 Impact factor: 15.992

3. A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear.

Authors: Anja Siegmund; Carsten T Wotjak
Journal: J Psychiatr Res Date: 2006-10-05 Impact factor: 4.791

4. Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic.

Authors: Patricia Tagliaferro; Marisela Morales
Journal: J Comp Neurol Date: 2008-02-01 Impact factor: 3.215

5. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study.

Authors: L W Swanson; P E Sawchenko; J Rivier; W W Vale
Journal: Neuroendocrinology Date: 1983 Impact factor: 4.914

6. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway.

Authors: Jessica J Walsh; Allyson K Friedman; Haosheng Sun; Elizabeth A Heller; Stacy M Ku; Barbara Juarez; Veronica L Burnham; Michelle S Mazei-Robison; Deveroux Ferguson; Sam A Golden; Ja Wook Koo; Dipesh Chaudhury; Daniel J Christoffel; Lisa Pomeranz; Jeffrey M Friedman; Scott J Russo; Eric J Nestler; Ming-Hu Han
Journal: Nat Neurosci Date: 2013-11-24 Impact factor: 24.884

7. Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice.

Authors: Anja Siegmund; Maik Dahlhoff; Ursula Habersetzer; Anna Mederer; Eckhard Wolf; Florian Holsboer; Carsten T Wotjak
Journal: J Psychiatr Res Date: 2009-03-21 Impact factor: 4.791

8. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.

Authors: Taryn E Grieder; Melissa A Herman; Candice Contet; Laura A Tan; Hector Vargas-Perez; Ami Cohen; Michal Chwalek; Geith Maal-Bared; John Freiling; Joel E Schlosburg; Laura Clarke; Elena Crawford; Pascale Koebel; Vez Repunte-Canonigo; Pietro P Sanna; Andrew R Tapper; Marisa Roberto; Brigitte L Kieffer; Paul E Sawchenko; George F Koob; Derek van der Kooy; Olivier George
Journal: Nat Neurosci Date: 2014-11-17 Impact factor: 24.884

9. Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward.

Authors: Yuval Silberman; Danny G Winder
Journal: Front Psychiatry Date: 2013-05-29 Impact factor: 4.157

10. Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity.

Authors: Julien Dine; Andreas Genewsky; Florian Hladky; Carsten T Wotjak; Jan M Deussing; Walter Zieglgänsberger; Alon Chen; Matthias Eder
Journal: Front Cell Neurosci Date: 2016-04-26 Impact factor: 5.505

33 in total

1. A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety.

Authors: Matthew B Pomrenze; Jorge Tovar-Diaz; Angelo Blasio; Rajani Maiya; Simone M Giovanetti; Kelly Lei; Hitoshi Morikawa; F Woodward Hopf; Robert O Messing
Journal: J Neurosci Date: 2018-12-10 Impact factor: 6.167

2. SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala.

Authors: Chenghua Zhou; Yuqing Wu; Xiaobao Ding; Naihao Shi; Youqin Cai; Zhizhong Z Pan
Journal: J Neurosci Date: 2020-01-31 Impact factor: 6.167

3. Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety.

Authors: Anne S Berry; Robert L White; Daniella J Furman; Jenna R Naskolnakorn; Vyoma D Shah; Mark D'Esposito; William J Jagust
Journal: J Neurosci Date: 2019-02-08 Impact factor: 6.167

4. Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice.

Authors: Biborka Bruzsik; Laszlo Biro; Dora Zelena; Eszter Sipos; Huba Szebik; Klara Rebeka Sarosdi; Orsolya Horvath; Imre Farkas; Veronika Csillag; Cintia Klaudia Finszter; Eva Mikics; Mate Toth
Journal: J Neurosci Date: 2021-01-19 Impact factor: 6.167