| Literature DB >> 29784850 |
Masaki Yamamoto1, Yasufumi Matsumura2, Ryota Gomi3, Tomonari Matsuda4, Satoshi Nakano2, Miki Nagao2, Michio Tanaka2, Satoshi Ichiyama2.
Abstract
A multidrug-resistant (MDR) Pseudomonas fulva strain was isolated in 2006 from a urine sample. The isolate harbored the blaIMP-1 gene, which was located in a chromosomal Tn402-like class 3 integron as a gene cassette array of aacA31-fosE-blaIMP-1 Two mutations in gyrA and one mutation in parC were detected in quinolone-resistance-determining regions (QRDRs). We report a full-length, novel, blaIMP-1-carrying class 3 integron. This integron, together with mutations in QRDRs, could have influenced the MDR phenotype.Entities:
Keywords: carbapenemase; class 3 integron; genetic environment; mechanisms of resistance; metallo-β-lactamases
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Year: 2018 PMID: 29784850 PMCID: PMC6105817 DOI: 10.1128/AAC.00701-18
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191