Eric Garshick1, Stephanie T Grady2, Jaime E Hart3, Brent A Coull4, Joel D Schwartz5, Francine Laden5, Marilyn L Moy6, Petros Koutrakis7. 1. Pulmonary, Allergy, Sleep, and Critical Care Medicine Section, Medical Service, VA Boston Healthcare System, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: eric.garshick@va.gov. 2. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA; Research and Development Service, VA Boston Healthcare System, Boston, MA, USA. 3. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 4. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 6. Pulmonary, Allergy, Sleep, and Critical Care Medicine Section, Medical Service, VA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. 7. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Abstract
RATIONALE: Evidence linking traffic-related particle exposure to systemic effects in chronic obstructive lung disease (COPD) patients is limited. OBJECTIVES: Assess relationships between indoor black carbon (BC), a tracer of traffic-related particles, and plasma biomarkers of systemic inflammation and endothelial activation. METHODS: BC was measured by reflectance in fine particle samples over a mean of 7.6 days in homes of 85 COPD patients up to 4 times seasonally over a year. After the completion of sampling, plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble vascular adhesion molecule-1 (sVCAM-1) were measured. Current smokers and homes with major sources of BC were excluded; therefore, indoor BC was primarily a measure of infiltrated outdoor BC. Mixed effects regression models with a random intercept for each participant were used to assess BC effects at different times (1-9 days before phlebotomy) and in the multi-day sample. RESULTS: Measured median BC was 0.19 µg/m3 (interquartile range, IQR=0.22 µg/m3). Adjusting for season, race, age, BMI, heart disease, diabetes, ambient temperature, relative humidity, a recent cold or similar illness, and blood draw time, there was a positive relationship between BC and CRP. The largest effect size was for BC averaged over the previous seven days (11.8% increase in CRP per IQR; 95%CI = 1.8-22.9). Effects were greatest among non-statin users and persons with diabetes. There were positive effects of BC on IL-6 only in non-statin users. There were no associations with sVCAM-1. CONCLUSIONS: These results demonstrate exposure-response relationships between indoor BC with biomarkers of systemic inflammation in COPD patients, with stronger relationships in persons not using statins and with diabetes. Published by Elsevier Inc.
RATIONALE: Evidence linking traffic-related particle exposure to systemic effects in chronic obstructive lung disease (COPD) patients is limited. OBJECTIVES: Assess relationships between indoor black carbon (BC), a tracer of traffic-related particles, and plasma biomarkers of systemic inflammation and endothelial activation. METHODS: BC was measured by reflectance in fine particle samples over a mean of 7.6 days in homes of 85 COPDpatients up to 4 times seasonally over a year. After the completion of sampling, plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble vascular adhesion molecule-1 (sVCAM-1) were measured. Current smokers and homes with major sources of BC were excluded; therefore, indoor BC was primarily a measure of infiltrated outdoor BC. Mixed effects regression models with a random intercept for each participant were used to assess BC effects at different times (1-9 days before phlebotomy) and in the multi-day sample. RESULTS: Measured median BC was 0.19 µg/m3 (interquartile range, IQR=0.22 µg/m3). Adjusting for season, race, age, BMI, heart disease, diabetes, ambient temperature, relative humidity, a recent cold or similar illness, and blood draw time, there was a positive relationship between BC and CRP. The largest effect size was for BC averaged over the previous seven days (11.8% increase in CRP per IQR; 95%CI = 1.8-22.9). Effects were greatest among non-statin users and persons with diabetes. There were positive effects of BC on IL-6 only in non-statin users. There were no associations with sVCAM-1. CONCLUSIONS: These results demonstrate exposure-response relationships between indoor BC with biomarkers of systemic inflammation in COPDpatients, with stronger relationships in persons not using statins and with diabetes. Published by Elsevier Inc.
Entities:
Keywords:
Air pollution; Biomarkers; Black carbon; COPD; Inflammation
Authors: Iny Jhun; Jina Kim; Bennet Cho; Diane R Gold; Joel Schwartz; Brent A Coull; Antonella Zanobetti; Mary B Rice; Murray A Mittleman; Eric Garshick; Pantel Vokonas; Marie-Abele Bind; Elissa H Wilker; Francesca Dominici; Helen Suh; Petros Koutrakis Journal: J Air Waste Manag Assoc Date: 2019-08 Impact factor: 2.235
Authors: Carolina L Z Vieira; Petros Koutrakis; Shaodan Huang; Stephanie Grady; Jaime E Hart; Brent A Coull; Francine Laden; Weeberb Requia; Joel Schwartz; Eric Garshick Journal: Environ Res Date: 2019-05-21 Impact factor: 6.498
Authors: Jessica R Deslauriers; Carrie A Redlich; Choong-Min Kang; Stephanie T Grady; Martin Slade; Petros Koutrakis; Eric Garshick Journal: J Expo Sci Environ Epidemiol Date: 2022-01-25 Impact factor: 6.371
Authors: Shaodan Huang; Eric Garshick; Carolina L Z Vieira; Stephanie T Grady; Joel D Schwartz; Brent A Coull; Jaime E Hart; Francine Laden; Petros Koutrakis Journal: Environ Res Date: 2019-10-19 Impact factor: 6.498
Authors: Emma Busenkell; Christina M Collins; Marilyn L Moy; Jaime E Hart; Stephanie T Grady; Brent A Coull; Joel D Schwartz; Petros Koutrakis; Eric Garshick Journal: Environ Res Date: 2022-01-29 Impact factor: 8.431