[INFLUENCE OF SAUSSUREA CONTROVERSA AND FILLIPENDULA ULMARIA EXTRACTS ON IMMUNOLOGICAL REACTIVITY OF RATS WITH EXPERIMENTAL OSTEOMYELITIS.]

The influence of Saussurea controversa DC and Fillipendula ulmaria (L.) Maxim extracts on the immunological reactivity of rats with experimental osteomyelitis has been studied. The application of these extracts on the background of antibiotic therapy normalized the immunological reactivity indices: (i) reduced the levels of total immunoglobulins, IgM and IgG and (ii) increased the percentage of active neutrophils and their absorption capacity, as well as the percentage of completion of phagocytosis. The treatment with plant extracts reduced the acute inflammatory reaction and increased the total number of megakaryocites as compared to those upon antibiotic therapy.