| Literature DB >> 29781814 |
Cissy Kityo1, Krystelle Nganou Makamdop2, Meghan Rothenberger3, Jeffrey G Chipman3, Torfi Hoskuldsson3, Gregory J Beilman3, Bartosz Grzywacz3, Peter Mugyenyi1, Francis Ssali1, Rama S Akondy4, Jodi Anderson3, Thomas E Schmidt3, Thomas Reimann3, Samuel P Callisto3, Jordan Schoephoerster3, Jared Schuster3, Proscovia Muloma1, Patrick Ssengendo1, Eirini Moysi2, Constantinos Petrovas2, Ray Lanciotti5, Lin Zhang3, Maria T Arévalo6, Benigno Rodriguez7, Ted M Ross6, Lydie Trautmann8,9, Rafick-Pierre Sekaly7, Michael M Lederman7, Richard A Koup10, Rafi Ahmed4, Cavan Reilly3, Daniel C Douek2, Timothy W Schacker3.
Abstract
Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.Entities:
Keywords: Adaptive immunity; Bacterial vaccines; Fibrosis; Immunology; Vaccines
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Year: 2018 PMID： 29781814 PMCID： PMC6025977 DOI： 10.1172/JCI97377
Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808