E El-Serougy1, H S Zayed1, N M Ibrahim2, L A Maged1. 1. Rheumatology and Rehabilitation Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt. 2. Chemical and Clinical Pathology Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt.
Abstract
OBJECTIVE: The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients. PATIENTS AND METHODS: Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay. RESULTS: SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5-100.9) and 10.3 (5.4-23.1) mg/l, respectively), p<0.001). CONCLUSION: Serum PCT could not differentiate SLE patients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed.
OBJECTIVE: The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients. PATIENTS AND METHODS: Sixty-nine SLEpatients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLEpatients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay. RESULTS:SLEpatients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5-100.9) and 10.3 (5.4-23.1) mg/l, respectively), p<0.001). CONCLUSION: Serum PCT could not differentiate SLEpatients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed.
Authors: Gangadharaiah Bharath; Prabhat Kumar; Nayani Makkar; Paras Singla; Manish Soneja; Ashutosh Biswas; Naveet Wig Journal: J Family Med Prim Care Date: 2019-07