Literature DB >> 29779115

The First Recombinant Viper Three-Finger Toxins: Inhibition of Muscle and Neuronal Nicotinic Acetylcholine Receptors.

Ya V Makarova1, E V Kryukova2, I V Shelukhina2, D S Lebedev2, T V Andreeva2, D Yu Ryazantsev2, S V Balandin2, T V Ovchinnikova2,3, V I Tsetlin2, Yu N Utkin2.   

Abstract

Genes encoding two three-finger toxins TFT-AF and TFT-VN, nucleotide sequences of which were earlier determined by cloning cDNA from venom glands of vipers Azemiops feae and Vipera nikolskii, respectively, were expressed for the first time in E. coli cells. The biological activity of these toxins was studied by electrophysiological techniques, calcium imaging, and radioligand analysis. It was shown for the first time that viper three-finger toxins are antagonists of nicotinic acetylcholine receptors of neuronal and muscle type.

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Year:  2018        PMID： 29779115     DOI： 10.1134/S1607672918020205

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

1.  "Weak toxin" from Naja kaouthia is a nontoxic antagonist of alpha 7 and muscle-type nicotinic acetylcholine receptors.

Authors:  Y N Utkin; V V Kukhtina; E V Kryukova; F Chiodini; D Bertrand; C Methfessel; V I Tsetlin
Journal:  J Biol Chem       Date:  2001-02-15       Impact factor: 5.157

Review 2.  Non-conventional toxins from Elapid venoms.

Authors:  S Nirthanan; P Gopalakrishnakone; M C E Gwee; H E Khoo; R M Kini
Journal:  Toxicon       Date:  2003-03       Impact factor: 3.033

Review 3.  Three-finger alpha-neurotoxins and the nicotinic acetylcholine receptor, forty years on.

Authors:  Selvanayagam Nirthanan; Matthew C E Gwee
Journal:  J Pharmacol Sci       Date:  2004-01       Impact factor: 3.337

Review 4.  The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily.

Authors:  Jean-Pierre Changeux
Journal:  J Biol Chem       Date:  2012-10-04       Impact factor: 5.157

Review 5.  Neuronal nicotinic receptors in the human brain.

Authors:  D Paterson; A Nordberg
Journal:  Prog Neurobiol       Date:  2000-05       Impact factor: 11.685

Review 6.  Mammalian nicotinic acetylcholine receptors: from structure to function.

Authors:  Edson X Albuquerque; Edna F R Pereira; Manickavasagom Alkondon; Scott W Rogers
Journal:  Physiol Rev       Date:  2009-01       Impact factor: 37.312

Review 7.  Understanding the molecular mechanism underlying the presynaptic toxicity of secreted phospholipases A2.

Authors:  Joze Pungercar; Igor Krizaj
Journal:  Toxicon       Date:  2007-08-22       Impact factor: 3.033

8.  Characterization of Nicotinic Acetylcholine Receptors Expressed by Cells of the SH-SY5Y Human Neuroblastoma Clonal Line.

Authors:  R J Lukas; S A Norman; L Lucero
Journal:  Mol Cell Neurosci       Date:  1993-02       Impact factor: 4.314

9.  Molecular properties and structure-function relationships of lethal peptides from venom of Wagler's pit viper, Trimeresurus wagleri.

Authors:  J J Schmidt; S A Weinstein; L A Smith
Journal:  Toxicon       Date:  1992-09       Impact factor: 3.033

10.  Design of new α-conotoxins: from computer modeling to synthesis of potent cholinergic compounds.

Authors:  Igor E Kasheverov; Maxim N Zhmak; Alexey Y Khruschov; Victor I Tsetlin
Journal:  Mar Drugs       Date:  2011-09-28       Impact factor: 6.085
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  3 in total

Review 1.  Old World Vipers-A Review about Snake Venom Proteomics of Viperinae and Their Variations.

Authors:  Maik Damm; Benjamin-Florian Hempel; Roderich D Süssmuth
Journal:  Toxins (Basel)       Date:  2021-06-17       Impact factor: 4.546

Review 2.  Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays.

Authors:  Reka A Otvos; Kristina B M Still; Govert W Somsen; August B Smit; Jeroen Kool
Journal:  SLAS Discov       Date:  2019-01-25       Impact factor: 3.341

3.  Novel Bradykinin-Potentiating Peptides and Three-Finger Toxins from Viper Venom: Combined NGS Venom Gland Transcriptomics and Quantitative Venom Proteomics of the Azemiops feae Viper.

Authors:  Vladislav V Babenko; Rustam H Ziganshin; Christoph Weise; Igor Dyachenko; Elvira Shaykhutdinova; Arkady N Murashev; Maxim Zhmak; Vladislav Starkov; Anh Ngoc Hoang; Victor Tsetlin; Yuri Utkin
Journal:  Biomedicines       Date:  2020-07-28
  3 in total

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