Literature DB >> 29779110

Translocation of Oligonucleotide-Oligosaccharide Complexes into Cells of the Brain.

N N Dygalo1,2, T S Kalinina3,4, D A Lanshakov3.   

Abstract

Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

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Year:  2018        PMID： 29779110     DOI： 10.1134/S160767291802014X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  8 in total

1.  Influence of neonatal short-term reduction in brainstem alpha2A-adrenergic receptors on receptor ontogenesis, acoustic startle reflex, and prepulse inhibition in rats.

Authors:  Galina T Shishkina; Tatjana S Kalinina; Nina K Popova; Nikolai N Dygalo
Journal:  Behav Neurosci       Date:  2004-12       Impact factor: 1.912

Review 2.  The delivery of therapeutic oligonucleotides.

Authors:  Rudolph L Juliano
Journal:  Nucleic Acids Res       Date:  2016-04-15       Impact factor: 16.971

3.  Dexamethasone-induced acute excitotoxic cell death in the developing brain.

Authors:  Dmitriy A Lanshakov; Ekaterina V Sukhareva; Tatjana S Kalinina; Nikolay N Dygalo
Journal:  Neurobiol Dis       Date:  2016-02-09       Impact factor: 5.996

Review 4.  Sugar Based Biopolymers in Nanomedicine; New Emerging Era for Cancer Imaging and Therapy.

Authors:  Mehmet S Eroglu; Ebru Toksoy Oner; Esra Cansever Mutlu; Muge Sennaroglu Bostan
Journal:  Curr Top Med Chem       Date:  2017       Impact factor: 3.295

Review 5.  Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases.

Authors:  Kathleen M Schoch; Timothy M Miller
Journal:  Neuron       Date:  2017-06-21       Impact factor: 17.173

6.  Radiation technology in the preparation of polyethylene oxide hydrophilic gels and immobilization of proteases for use in medical practice.

Authors:  E I Vereschagin; D H Han; A W Troitsky; O V Grishin; S E Petrov; E P Gulyaeva; L A Bogdanova; M V Korobeinikov; V L Auslender
Journal:  Arch Pharm Res       Date:  2001-06       Impact factor: 4.946

7.  Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect.

Authors:  G T Shishkina; T S Kalinina; N N Dygalo
Journal:  Neuroscience       Date:  2007-09-14       Impact factor: 3.590

8.  Neonatal programming of rat behavior by downregulation of alpha2A-adrenoreceptor gene expression in the brain.

Authors:  Nikolay N Dygalo; Tatyana S Kalinina; Galina T Shishkina
Journal:  Ann N Y Acad Sci       Date:  2008-12       Impact factor: 5.691
  8 in total

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