Literature DB >> 29779097

MNT Optimization for Intracellular Delivery of Antibody Fragments.

A V Ulasov1, Y V Khramtsov1, T N Lupanova1, A D Tsvetkova1,2, A A Rosenkranz1,2, T A Slastnikova1, G P Georgiev1, A S Sobolev3,4.   

Abstract

We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.

Mesh：

Substances：

Year:  2018        PMID： 29779097     DOI： 10.1134/S1607672918020023

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

1.  Expression of single chain antibodies (ScFvs) for c-myc oncoprotein in recombinant Escherichia coli membranes by using the ice-nucleation protein of Pseudomonas syringae.

Authors:  A S Bassi; D N Ding; G B Gloor; A Margaritis
Journal:  Biotechnol Prog       Date:  2000 Jul-Aug

Review 2.  Targeting antibodies to the cytoplasm.

Authors:  Andrea L J Marschall; André Frenzel; Thomas Schirrmann; Manuela Schüngel; Stefan Dübel
Journal:  MAbs       Date:  2011-01-01       Impact factor: 5.857

3.  Targeting cancer cells by novel engineered modular transporters.

Authors:  Dinara G Gilyazova; Andrey A Rosenkranz; Pavel V Gulak; Vladimir G Lunin; Olga V Sergienko; Yuri V Khramtsov; Kirill N Timofeyev; Mikhail A Grin; Andrey F Mironov; Andrey B Rubin; Georgii P Georgiev; Alexander S Sobolev
Journal:  Cancer Res       Date:  2006-11-01       Impact factor: 12.701

Review 4.  The translational potential for target validation and therapy using intracellular antibodies in oncology.

Authors:  Ulrich H Weidle; Daniela Maisel; Ulrich Brinkmann; Georg Tiefenthaler
Journal:  Cancer Genomics Proteomics       Date:  2013 Nov-Dec       Impact factor: 4.069

5.  Modular drug transporters with diphtheria toxin translocation domain form edged holes in lipid membranes.

Authors:  Yuri V Khramtsov; Tatyana I Rokitskaya; Andrey A Rosenkranz; Georgiy A Trusov; Nikolay V Gnuchev; Yuri N Antonenko; Alexander S Sobolev
Journal:  J Control Release       Date:  2008-03-19       Impact factor: 9.776

Review 6.  Drugging the 'undruggable' cancer targets.

Authors:  Chi V Dang; E Premkumar Reddy; Kevan M Shokat; Laura Soucek
Journal:  Nat Rev Cancer       Date:  2017-06-23       Impact factor: 60.716

Review 7.  Drugging Undruggable Molecular Cancer Targets.

Authors:  John S Lazo; Elizabeth R Sharlow
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-11-02       Impact factor: 13.820

8.  Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At.

Authors:  Andrey A Rosenkranz; Ganesan Vaidyanathan; Oscar R Pozzi; Vladimir G Lunin; Michael R Zalutsky; Alexander S Sobolev
Journal:  Int J Radiat Oncol Biol Phys       Date:  2008-09-01       Impact factor: 7.038

9.  Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Natalia B Morozova; Maria S Vorontsova; Vasiliy M Petriev; Tatiana N Lupanova; Alexey V Ulasov; Michael R Zalutsky; Raisa I Yakubovskaya; Alexander S Sobolev
Journal:  Int J Nanomedicine       Date:  2017-01-10

10.  Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I.

Authors:  Tatiana A Slastnikova; Eftychia Koumarianou; Andrey A Rosenkranz; Ganesan Vaidyanathan; Tatiana N Lupanova; Alexander S Sobolev; Michael R Zalutsky
Journal:  EJNMMI Res       Date:  2012-10-29       Impact factor: 3.138
View more
  3 in total

1.  Demonstration of intracellular trafficking, cytosolic bioavailability, and target manipulation of an antibody delivery platform.

Authors:  Wei Lv; Julie A Champion
Journal:  Nanomedicine       Date:  2020-10-13       Impact factor: 5.307

Review 2.  Targeted Intracellular Delivery of Antibodies: The State of the Art.

Authors:  Tatiana A Slastnikova; A V Ulasov; A A Rosenkranz; A S Sobolev
Journal:  Front Pharmacol       Date:  2018-10-24       Impact factor: 5.810

3.  The Delivery of Biologically Active Agents into the Nuclei of Target Cells for the Purposes of Translational Medicine.

Authors:  A S Sobolev
Journal:  Acta Naturae       Date:  2020 Oct-Dec       Impact factor: 1.845
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.