| Literature DB >> 29777944 |
M Monticelli1, P Zeppa2, F Zenga2, R Altieri2, M Mammi2, L Bertero3, I Castellano3, P Cassoni3, A Melcarne2, G La Rocca4, G Sabatino4, A Ducati2, D Garbossa2.
Abstract
Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior. The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.Entities:
Keywords: BRAF; Glioblastoma; High grade gliomas; IDH1; IDH2; MGMT; Molecular biology; TERT
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Year: 2018 PMID： 29777944 DOI： 10.1016/j.clineuro.2018.05.015
Source DB: PubMed Journal: Clin Neurol Neurosurg ISSN： 0303-8467 Impact factor: 1.876