Jian-Wen Xiong1, Bo Wei1, Yan-Kun Li2, Jin-Qiong Zhan3, Shu-Zhen Jiang4, Hai-Bo Chen1, Kun Yan3, Bin Yu5,6, Yuan-Jian Yang7,8. 1. Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Number 43, Shangfang Road, Nanchang, 330029, People's Republic of China. 2. Department of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, 437100, People's Republic of China. 3. Medical Experimental Center, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, 330029, People's Republic of China. 4. Department of Pharmacy, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, 330029, People's Republic of China. 5. Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Number 43, Shangfang Road, Nanchang, 330029, People's Republic of China. jxmh_yb@163.com. 6. Medical Experimental Center, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, 330029, People's Republic of China. jxmh_yb@163.com. 7. Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Number 43, Shangfang Road, Nanchang, 330029, People's Republic of China. yuanjimyang@yeah.net. 8. Medical Experimental Center, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, 330029, People's Republic of China. yuanjimyang@yeah.net.
Abstract
OBJECTIVE: Aberrant N-methyl-D-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that regulates NMDAR function. The current study investigated the relationship between plasma H2S levels and both psychopathological and cognitive symptoms in schizophrenia. MATERIALS AND METHODS: Forty-one patients with schizophrenia and 40 healthy control subjects were recruited in present study. Schizophrenic symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). Cognitive function was evaluated with a neuropsychological battery including seven neurocognitive tests. Plasma H2S levels were measured by reversed-phase high-performance liquid chromatography (RP-HPLC). RESULTS: Patients with schizophrenia performed worse in all of the cognitive tests than the healthy controls except for the visual memory. Plasma H2S levels were significantly lower in patients with schizophrenia relative to healthy control subjects (F = 3.821, p = 0.007). Correlation analysis revealed a significant negative correlation between the H2S levels and the PANSS general scores (r = - 0.413, p = 0.007). Additionally, a positive association was observed between plasma H2S levels and working memory (r = 0.416, p = 0.007), visual memory (r = 0.363, p = 0.020), or executive function (r = 0.344, p = 0.028) in patients. Partial correlation analysis showed that the correlations between the H2S levels and the PANSS general scores, working memory, visual memory, or executive function were still significant when controlling for age, gender, years of education, BMI, duration of illness, and age of onset. CONCLUSION: The significant relations observed in the current study between H2S and the general psychopathological as well as cognitive symptoms suggest that decreased H2S is involved in the psychopathology and cognitive deficits of schizophrenia, and it might be a promising peripheral biomarker of schizophrenia.
OBJECTIVE: Aberrant N-methyl-D-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that regulates NMDAR function. The current study investigated the relationship between plasma H2S levels and both psychopathological and cognitive symptoms in schizophrenia. MATERIALS AND METHODS: Forty-one patients with schizophrenia and 40 healthy control subjects were recruited in present study. Schizophrenic symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). Cognitive function was evaluated with a neuropsychological battery including seven neurocognitive tests. Plasma H2S levels were measured by reversed-phase high-performance liquid chromatography (RP-HPLC). RESULTS:Patients with schizophrenia performed worse in all of the cognitive tests than the healthy controls except for the visual memory. Plasma H2S levels were significantly lower in patients with schizophrenia relative to healthy control subjects (F = 3.821, p = 0.007). Correlation analysis revealed a significant negative correlation between the H2S levels and the PANSS general scores (r = - 0.413, p = 0.007). Additionally, a positive association was observed between plasma H2S levels and working memory (r = 0.416, p = 0.007), visual memory (r = 0.363, p = 0.020), or executive function (r = 0.344, p = 0.028) in patients. Partial correlation analysis showed that the correlations between the H2S levels and the PANSS general scores, working memory, visual memory, or executive function were still significant when controlling for age, gender, years of education, BMI, duration of illness, and age of onset. CONCLUSION: The significant relations observed in the current study between H2S and the general psychopathological as well as cognitive symptoms suggest that decreased H2S is involved in the psychopathology and cognitive deficits of schizophrenia, and it might be a promising peripheral biomarker of schizophrenia.
Authors: Xiang Yang Zhang; Jun Liang; Da Chun Chen; Mei Hong Xiu; Fu De Yang; Therese A Kosten; Thomas R Kosten Journal: Psychopharmacology (Berl) Date: 2012-01-26 Impact factor: 4.530
Authors: Alberto Ferreira Donatti; Renato Nery Soriano; Christie Ramos Andrade Leite-Panissi; Luiz G S Branco; Albert Schiaveto de Souza Journal: Neurosci Lett Date: 2017-01-26 Impact factor: 3.046
Authors: Jian-Wen Xiong; Jin-Qiong Zhan; Tao Luo; Hai-Bo Chen; Qi-Gen Wan; Yan Wang; Bo Wei; Yuan-Jian Yang Journal: Front Neurosci Date: 2020-06-16 Impact factor: 4.677
Authors: Olaf Sommer; Rosana L Aug; Andreas J Schmidt; Philip Heiser; Eberhard Schulz; Helmut Vedder; Hans-Willi Clement Journal: Front Psychiatry Date: 2018-10-16 Impact factor: 4.157
Authors: Zhi-Min Yu; Ying Zhao; Jin-Qiong Zhan; Tao Luo; Jian-Wen Xiong; Bin Yu; Bo Wei; Yuan-Jian Yang Journal: Front Psychiatry Date: 2019-01-10 Impact factor: 4.157