Gregory J Czuczman1, Daniel E Marrero2, Ambrose J Huang3, Jacob C Mandell4, Varand Ghazikhanian4, F Joseph Simeone3. 1. Radiology Imaging Associates, PC, Englewood, CO, USA. gregory.czuczman@riaco.com. 2. Norwich Diagnostic Imaging Associates, PC, Norwich, CT, USA. 3. Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4. Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
OBJECTIVE: The purpose of this study was to examine the yield of repeat CT-guided biopsy in patients with suspected infectious spondylodiscitis following an initial biopsy with negative microbiology, and to identify factors associated with successful pathogen isolation. MATERIALS AND METHODS: In this retrospective study, 21 patients (12 men, 9 women; mean age, 52, range, 12-84) were identified with clinically and radiologically suspected infectious spondylodiscitis who underwent repeat biopsy following negative cultures from an initial biopsy. The microbe yield as well as demographic, clinical, and laboratory findings were reviewed and statistical analysis was performed. RESULTS: Repeat CT-guided biopsy isolated a causative microbe in 3/21 patients (14.3%). Younger age (p = 0.021) was significantly associated with successful microbe isolation. All three cases of successful microbe isolation occurred in patients not exposed to antibiotics (3/9 patients) whereas no successful microbe isolation occurred in patients who received antibiotics (0/12 patients); however, this difference did not reach statistical significance (p = 0.062). Gender, duration of symptoms, white blood cell count, biopsy interval, and biopsy site were not significantly associated with microbe isolation. CONCLUSIONS: Overall microbiologic yield of repeat CT-guided biopsy for patients with suspected infectious spondylodiscitis was low at 14.3%; however, a higher yield was identified in patients who were younger in age and not exposed to pre-biopsy antibiotics.
OBJECTIVE: The purpose of this study was to examine the yield of repeat CT-guided biopsy in patients with suspected infectious spondylodiscitis following an initial biopsy with negative microbiology, and to identify factors associated with successful pathogen isolation. MATERIALS AND METHODS: In this retrospective study, 21 patients (12 men, 9 women; mean age, 52, range, 12-84) were identified with clinically and radiologically suspected infectious spondylodiscitis who underwent repeat biopsy following negative cultures from an initial biopsy. The microbe yield as well as demographic, clinical, and laboratory findings were reviewed and statistical analysis was performed. RESULTS: Repeat CT-guided biopsy isolated a causative microbe in 3/21 patients (14.3%). Younger age (p = 0.021) was significantly associated with successful microbe isolation. All three cases of successful microbe isolation occurred in patients not exposed to antibiotics (3/9 patients) whereas no successful microbe isolation occurred in patients who received antibiotics (0/12 patients); however, this difference did not reach statistical significance (p = 0.062). Gender, duration of symptoms, white blood cell count, biopsy interval, and biopsy site were not significantly associated with microbe isolation. CONCLUSIONS: Overall microbiologic yield of repeat CT-guided biopsy for patients with suspected infectious spondylodiscitis was low at 14.3%; however, a higher yield was identified in patients who were younger in age and not exposed to pre-biopsy antibiotics.
Authors: Eugenio Rimondi; Eric L Staals; Costantino Errani; Giuseppe Bianchi; Roberto Casadei; Marco Alberghini; Maria Cristina Malaguti; Giuseppe Rossi; Stefano Durante; Mario Mercuri Journal: Eur Spine J Date: 2008-05-08 Impact factor: 3.134
Authors: G Gras; R Buzele; J J Parienti; F Debiais; A Dinh; M Dupon; F Roblot; D Mulleman; C Marcelli; J Michon; L Bernard Journal: Eur J Clin Microbiol Infect Dis Date: 2013-09-21 Impact factor: 3.267
Authors: William Terreaux; Marion Geoffroy; Xavier Ohl; Louis Job; Philippe Cart; Jean-Paul Eschard; Jean-Hugues Salmon Journal: Joint Bone Spine Date: 2016-04-20 Impact factor: 4.929
Authors: B Fouquet; P Goupille; F Jattiot; P Cotty; F Lapierre; J P Valat; J Amouroux; A Benatre Journal: Spine (Phila Pa 1976) Date: 1992-03 Impact factor: 3.468
Authors: Chung-Jong Kim; Kyoung-Ho Song; Wan Beom Park; Eu Suk Kim; Sang Won Park; Hong-Bin Kim; Myoung-don Oh; Nam Joong Kim Journal: Antimicrob Agents Chemother Date: 2012-01-09 Impact factor: 5.191
Authors: Franck Grados; François Xavier Lescure; Eric Senneville; René Marc Flipo; Jean Luc Schmit; Patrice Fardellone Journal: Joint Bone Spine Date: 2007-02-02 Impact factor: 4.929
Authors: Fardad T Afshari; Desiderio Rodrigues; Mahesh Bhat; Guirish A Solanki; A Richard Walsh; William B Lo Journal: Childs Nerv Syst Date: 2019-12-17 Impact factor: 1.475
Authors: Lawrence A Lavery; P Andrew Crisologo; Javier La Fontaine; Kavitha Bhavan; Orhan K Oz; Kathryn E Davis Journal: J Foot Ankle Surg Date: 2019-07 Impact factor: 1.286