Laura M Lyall1, Cathy A Wyse2, Nicholas Graham3, Amy Ferguson3, Donald M Lyall3, Breda Cullen3, Carlos A Celis Morales4, Stephany M Biello5, Daniel Mackay3, Joey Ward3, Rona J Strawbridge6, Jason M R Gill4, Mark E S Bailey7, Jill P Pell3, Daniel J Smith3. 1. Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. Electronic address: laura.lyall@glasgow.ac.uk. 2. Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; Department of Molecular and Cellular Therapeutics, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland. 3. Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. 4. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. 5. School of Psychology, University of Glasgow, Glasgow, UK. 6. Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK; Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden. 7. School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Abstract
BACKGROUND: Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder. METHODS: UK residents aged 37-73 years were recruited into the UK Biobank general population cohort from 2006 to 2010. We used data from a subset of participants whose activity levels were recorded by wearing a wrist-worn accelerometer for 7 days. From these data, we derived a circadian relative amplitude variable, which is a measure of the extent to which circadian rhythmicity of rest-activity cycles is disrupted. In the same sample, we examined cross-sectional associations between low relative amplitude and mood disorder, wellbeing, and cognitive variables using a series of regression models. Our final model adjusted for age and season at the time that accelerometry started, sex, ethnic origin, Townsend deprivation score, smoking status, alcohol intake, educational attainment, overall mean acceleration recorded by accelerometry, body-mass index, and a binary measure of childhood trauma. FINDINGS: We included 91 105 participants with accelerometery data collected between 2013 and 2015 in our analyses. A one-quintile reduction in relative amplitude was associated with increased risk of lifetime major depressive disorder (odds ratio [OR] 1·06, 95% CI 1·04-1·08) and lifetime bipolar disorder (1·11, 1·03-1·20), as well as with greater mood instability (1·02, 1·01-1·04), higher neuroticism scores (incident rate ratio 1·01, 1·01-1·02), more subjective loneliness (OR 1·09, 1·07-1·11), lower happiness (0·91, 0·90-0·93), lower health satisfaction (0·90, 0·89-0·91), and slower reaction times (linear regression coefficient 1·75, 1·05-2·45). These associations were independent of demographic, lifestyle, education, and overall activity confounders. INTERPRETATION: Circadian disruption is reliably associated with various adverse mental health and wellbeing outcomes, including major depressive disorder and bipolar disorder. Lower relative amplitude might be linked to increased susceptibility to mood disorders. FUNDING: Lister Institute of Preventive Medicine.
BACKGROUND: Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder. METHODS: UK residents aged 37-73 years were recruited into the UK Biobank general population cohort from 2006 to 2010. We used data from a subset of participants whose activity levels were recorded by wearing a wrist-worn accelerometer for 7 days. From these data, we derived a circadian relative amplitude variable, which is a measure of the extent to which circadian rhythmicity of rest-activity cycles is disrupted. In the same sample, we examined cross-sectional associations between low relative amplitude and mood disorder, wellbeing, and cognitive variables using a series of regression models. Our final model adjusted for age and season at the time that accelerometry started, sex, ethnic origin, Townsend deprivation score, smoking status, alcohol intake, educational attainment, overall mean acceleration recorded by accelerometry, body-mass index, and a binary measure of childhood trauma. FINDINGS: We included 91 105 participants with accelerometery data collected between 2013 and 2015 in our analyses. A one-quintile reduction in relative amplitude was associated with increased risk of lifetime major depressive disorder (odds ratio [OR] 1·06, 95% CI 1·04-1·08) and lifetime bipolar disorder (1·11, 1·03-1·20), as well as with greater mood instability (1·02, 1·01-1·04), higher neuroticism scores (incident rate ratio 1·01, 1·01-1·02), more subjective loneliness (OR 1·09, 1·07-1·11), lower happiness (0·91, 0·90-0·93), lower health satisfaction (0·90, 0·89-0·91), and slower reaction times (linear regression coefficient 1·75, 1·05-2·45). These associations were independent of demographic, lifestyle, education, and overall activity confounders. INTERPRETATION: Circadian disruption is reliably associated with various adverse mental health and wellbeing outcomes, including major depressive disorder and bipolar disorder. Lower relative amplitude might be linked to increased susceptibility to mood disorders. FUNDING: Lister Institute of Preventive Medicine.
Authors: Layla J Bunjo; Amy C Reynolds; Sarah L Appleton; Jill Dorrian; Céline Vetter; Tiffany K Gill; Robert J Adams Journal: Int J Behav Med Date: 2021-02
Authors: Masoud Tahmasian; André Aleman; Ole A Andreassen; Zahra Arab; Marion Baillet; Francesco Benedetti; Tom Bresser; Joanna Bright; Michael W L Chee; Daphne Chylinski; Wei Cheng; Michele Deantoni; Martin Dresler; Simon B Eickhoff; Claudia R Eickhoff; Torbjørn Elvsåshagen; Jianfeng Feng; Jessica C Foster-Dingley; Habib Ganjgahi; Hans J Grabe; Nynke A Groenewold; Tiffany C Ho; Seung Bong Hong; Josselin Houenou; Benson Irungu; Neda Jahanshad; Habibolah Khazaie; Hosung Kim; Ekaterina Koshmanova; Desi Kocevska; Peter Kochunov; Oti Lakbila-Kamal; Jeanne Leerssen; Meng Li; Annemarie I Luik; Vincenzo Muto; Justinas Narbutas; Gustav Nilsonne; Victoria S O'Callaghan; Alexander Olsen; Ricardo S Osorio; Sara Poletti; Govinda Poudel; Joyce E Reesen; Liesbeth Reneman; Mathilde Reyt; Dieter Riemann; Ivana Rosenzweig; Masoumeh Rostampour; Amin Saberi; Julian Schiel; Christina Schmidt; Anouk Schrantee; Emma Sciberras; Tim J Silk; Kang Sim; Hanne Smevik; Jair C Soares; Kai Spiegelhalder; Dan J Stein; Puneet Talwar; Sandra Tamm; Giana L Teresi; Sofie L Valk; Eus Van Someren; Gilles Vandewalle; Maxime Van Egroo; Henry Völzke; Martin Walter; Rick Wassing; Frederik D Weber; Antoine Weihs; Lars Tjelta Westlye; Margaret J Wright; Mon-Ju Wu; Nathalia Zak; Mojtaba Zarei Journal: J Sleep Res Date: 2021-04-28 Impact factor: 3.981