| Literature DB >> 29775783 |
Maulikkumar Patel1, Shanaya Patel1, Naman Mangukia1, Saumya Patel1, Archana Mankad1, Himanshu Pandya1, Rakesh Rawal2.
Abstract
O. basilicum is medicinally important herb having inevitable role in human health. However, the mechanism of action is largely unknown. Present study aims to understand the mechanism of regulation of key human target genes that could plausibly modulated by O. basilicum miRNAs in cross kingdom manner using computational and system biology approach. O. basilicum miRNA sequences were retrieved and their corresponding human target genes were identified using psRNA target and interaction analysis of hub nodes. Six O. basilicum derived miRNAs were found to modulate 26 human target genes which were associated `with PI3K-AKTand MAPK signaling pathways with PTPN11, EIF2S2, NOS1, IRS1 and USO1 as top 5 Hub nodes. O. basilicum miRNAs not only regulate key human target genes having a significance in various diseases but also paves the path for future studies that might explore potential of miRNA mediated cross-kingdom regulation, prevention and treatment of various human diseases including cancer.Entities:
Keywords: Cross kingdom regulation; Functional analysis; Ocimum basilicum; Pathway analysis; miRNA
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Year: 2018 PMID： 29775783 DOI： 10.1016/j.ygeno.2018.04.016
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736