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Literature DB >> 29775669

Nanogels as potential drug nanocarriers for CNS drug delivery.

Arti Vashist¹, Ajeet Kaushik², Atul Vashist³, Jyoti Bala², Roozbeh Nikkhah-Moshaie², Vidya Sagar², Madhavan Nair⁴.

Abstract

Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as tissue engineering, scaffolds, drug delivery, and regenerative medicines. The drawback of higher size and poor stability in such DDSs are being addressed by developing nano-sized hydrogel particles, known as nanogels, to achieve the desired biocompatibility and encapsulation efficiency for better efficacy than conventional bulk hydrogels. In this review, we describe advances in the development of nanogels and their promotion as nanocarriers to deliver therapeutic agents to the central nervous system (CNS). We also discuss the challenges, possible solutions, and future prospects for the use of nanogel-based DDSs for CNS therapies.

Entities: Chemical Disease Gene Species

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Year: 2018 PMID： 29775669 PMCID： PMC6598698 DOI： 10.1016/j.drudis.2018.05.018

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

53 in total

1. Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.

Authors: E V Batrakova; D W Miller; S Li; V Y Alakhov; A V Kabanov; W F Elmquist
Journal: J Pharmacol Exp Ther Date: 2001-02 Impact factor: 4.030

Review 2. Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system.

Authors: Gabriel A Silva
Journal: Surg Neurol Date: 2005-04

Review 3. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

Authors: David J Begley
Journal: Pharmacol Ther Date: 2004-10 Impact factor: 12.310

4. Pharmacokinetic and pharmacodynamic behaviour of antitubercular drugs encapsulated in alginate nanoparticles at two doses.

Authors: Zahoor Ahmad; Rajesh Pandey; Sadhna Sharma; Gopal K Khuller
Journal: Int J Antimicrob Agents Date: 2006-04-19 Impact factor: 5.283

Review 5. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells.

Authors: Serguei V Vinogradov; Tatiana K Bronich; Alexander V Kabanov
Journal: Adv Drug Deliv Rev Date: 2002-01-17 Impact factor: 15.470

6. Ion concentration of external solution as a characteristic of micro- and nanogel ionic reservoirs.

Authors: Sergey Kazakov; Marian Kaholek; Irina Gazaryan; Boris Krasnikov; Korki Miller; Kalle Levon
Journal: J Phys Chem B Date: 2006-08-10 Impact factor: 2.991

7. Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier.

Authors: S Mitra; U Gaur; P C Ghosh; A N Maitra
Journal: J Control Release Date: 2001-07-06 Impact factor: 9.776

8. Polytriazoles as copper(I)-stabilizing ligands in catalysis.

Authors: Timothy R Chan; Robert Hilgraf; K Barry Sharpless; Valery V Fokin
Journal: Org Lett Date: 2004-08-19 Impact factor: 6.005

9. Nanogels for oligonucleotide delivery to the brain.

Authors: Serguei V Vinogradov; Elena V Batrakova; Alexander V Kabanov
Journal: Bioconjug Chem Date: 2004 Jan-Feb Impact factor: 4.774

10. Protein refolding assisted by self-assembled nanogels as novel artificial molecular chaperone.

Authors: Yuta Nomura; Masahiro Ikeda; Nozomi Yamaguchi; Yasuhiro Aoyama; Kazunari Akiyoshi
Journal: FEBS Lett Date: 2003-10-23 Impact factor: 4.124

22 in total

Review 1. Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders.

Authors: Caroline Vissers; Guo-Li Ming; Hongjun Song
Journal: Adv Drug Deliv Rev Date: 2019-02-21 Impact factor: 15.470

2. Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation.

Authors: Ravinder Verma; Ajeet Kaushik; Rafa Almeer; Md Habibur Rahman; Mohamed M Abdel-Daim; Deepak Kaushik
Journal: Int J Nanomedicine Date: 2021-02-09

Review 3. Advances in Nano-Enabled Platforms for the Treatment of Depression.

Authors: Fadzai P Mutingwende; Pierre P D Kondiah; Philemon Ubanako; Thashree Marimuthu; Yahya E Choonara
Journal: Polymers (Basel) Date: 2021-04-29 Impact factor: 4.329

Review 4. Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine.

Authors: Arti Vashist; Ajeet Kaushik; Anujit Ghosal; Jyoti Bala; Roozbeh Nikkhah-Moshaie; Waseem A Wani; Pandiaraj Manickam; Madhavan Nair
Journal: Gels Date: 2018-09-06

5. Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp.

Authors: Trung Dinh Nguyen; The Ngoc Nguyen; Trang Thuy Thi Nguyen; Igor A Ivanov; Khoa Cuu Nguyen; Quyen Ngoc Tran; Anh Ngoc Hoang; Yuri N Utkin
Journal: Nanomaterials (Basel) Date: 2019-08-23 Impact factor: 5.076

Review 6. Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives ^‡.

Authors: Uladzimir Bildziukevich; Zülal Özdemir; Zdeněk Wimmer
Journal: Molecules Date: 2019-09-30 Impact factor: 4.411

7. Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical Applications.

Authors: Arti Vashist; Venkata Atluri; Andrea Raymond; Ajeet Kaushik; Tiyash Parira; Zaohua Huang; Andriy Durygin; Asahi Tomitaka; Roozbeh Nikkhah-Moshaie; Atul Vashist; Marisela Agudelo; Hitendra S Chand; Ilyas Saytashev; Jessica C Ramella-Roman; Madhavan Nair
Journal: Front Bioeng Biotechnol Date: 2020-04-30

Nanogels as potential drug nanocarriers for CNS drug delivery.

1. Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.

Review 2. Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system.

Review 3. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

4. Pharmacokinetic and pharmacodynamic behaviour of antitubercular drugs encapsulated in alginate nanoparticles at two doses.

Review 5. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells.

6. Ion concentration of external solution as a characteristic of micro- and nanogel ionic reservoirs.

7. Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier.

8. Polytriazoles as copper(I)-stabilizing ligands in catalysis.

9. Nanogels for oligonucleotide delivery to the brain.

10. Protein refolding assisted by self-assembled nanogels as novel artificial molecular chaperone.

Review 1. Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders.

2. Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation.

Review 3. Advances in Nano-Enabled Platforms for the Treatment of Depression.

Review 4. Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine.

5. Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp.

Review 6. Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives ^‡.

7. Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical Applications.

Review 8. Nanogel: A Versatile Nano-Delivery System for Biomedical Applications.

9. Combined Treatment with Three Natural Antioxidants Enhances Neuroprotection in a SH-SY5Y 3D Culture Model.

10. Protease Responsive Essential Amino-Acid Based Nanocarriers for Near-Infrared Imaging.

Review 2. Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system.

Review 3. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

Review 5. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells.

Review 1. Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders.

Review 3. Advances in Nano-Enabled Platforms for the Treatment of Depression.

Review 4. Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine.

Review 6. Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives ‡.

Review 8. Nanogel: A Versatile Nano-Delivery System for Biomedical Applications.

Review 6. Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives ^‡.