Manuel Martínez-Sellés1,2, Pablo Díez-Villanueva3, Jesús Álvarez Garcia4, Andreu Ferrero-Gregori4, Miquel Vives-Borrás4, Fernando Worner5, Alfredo Bardají6, Juan F Delgado7, Rafael Vázquez8, José R González-Juanatey9, Francisco Fernández-Aviles1, Juan Cinca4. 1. Cardiology Department, Hospital General Universitario Gregorio Marañón, CIBERCV, Universidad Complutense, Madrid, Spain. 2. Universidad Europea, Madrid, Spain. 3. Cardiology Department, Hospital Universitario de la Princesa, Madrid, Spain. 4. Cardiology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. 5. Cardiology Department, Hospital Universitari Arnau de Vilanova, Instituto de Investigación Biomédica de Lleida, Lleida (IRB LLEIDA), Spain. 6. Cardiology Department, Hospital Universitario de Tarragona Joan XXIII, IISPV, Universidad Rovira Virgili, Tarragona, Spain. 7. Cardiology Department, Hospital General Universitario 12 de Octubre, Madrid, Spain. 8. Cardiology Department, Hospital Universitario Puerta del Mar, Cádiz, Spain. 9. Cardiology Department, Hospital Universitario, Santiago de Compostela, Spain.
Abstract
BACKGROUND: Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system. HYPOTHESIS: Sex and previous gestations might have a prognostic impact on 1-year mortality in patients admitted with HF. METHODS: We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF. RESULTS: Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values <0.001). During 1-year follow-up, 373 (20.4%) patients died (151 females and 222 males). Female sex was an independent predictor for survival (hazard ratio: 0.79, 95% confidence interval: 0.64-0.98, P = 0.03). In 504 women (65.9%), the exact number of previous pregnancies could be determined; 62 women (12.3%) had no previous pregnancies, 288 (57.1%) women had 1 or 2 pregnancies, and 154 women (30.6%) had ≥3 pregnancies. We found an association between the number of previous gestations and better survival (hazard ratio: 0.878, 95% confidence interval: 0.773-0.997, P = 0.045). CONCLUSIONS: In patients admitted with HF, female sex and the number of previous pregnancies are independently associated with better 1-year survival.
BACKGROUND: Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system. HYPOTHESIS: Sex and previous gestations might have a prognostic impact on 1-year mortality in patients admitted with HF. METHODS: We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF. RESULTS: Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values <0.001). During 1-year follow-up, 373 (20.4%) patients died (151 females and 222 males). Female sex was an independent predictor for survival (hazard ratio: 0.79, 95% confidence interval: 0.64-0.98, P = 0.03). In 504 women (65.9%), the exact number of previous pregnancies could be determined; 62 women (12.3%) had no previous pregnancies, 288 (57.1%) women had 1 or 2 pregnancies, and 154 women (30.6%) had ≥3 pregnancies. We found an association between the number of previous gestations and better survival (hazard ratio: 0.878, 95% confidence interval: 0.773-0.997, P = 0.045). CONCLUSIONS: In patients admitted with HF, female sex and the number of previous pregnancies are independently associated with better 1-year survival.
Authors: Manuel Martínez-Sellés; Robert N Doughty; Katrina Poppe; Gillian A Whalley; Nikki Earle; Christophe Tribouilloy; John J V McMurray; Karl Swedberg; Lars Køber; Colin Berry; Iain Squire Journal: Eur J Heart Fail Date: 2012-03-08 Impact factor: 15.534
Authors: Antoni Bayes-Genis; Beatriz Bellosillo; Oscar de la Calle; Marta Salido; Santiago Roura; Francesc Solé Ristol; Carolina Soler; Monica Martinez; Blanca Espinet; Sergi Serrano; Antoni Bayes de Luna; Juan Cinca Journal: J Heart Lung Transplant Date: 2005-09-28 Impact factor: 10.247
Authors: Manuel Martínez-Sellés; Marta Domínguez Muñoa; Esther Martínez; Miguel Angel García Fernández; Eulogio García Journal: Eur J Heart Fail Date: 2006-02-28 Impact factor: 15.534
Authors: Eileen O'Meara; Tim Clayton; Margaret B McEntegart; John J V McMurray; Ileana L Piña; Christopher B Granger; Jan Ostergren; Eric L Michelson; Scott D Solomon; Stuart Pocock; Salim Yusuf; Karl Swedberg; Marc A Pfeffer Journal: Circulation Date: 2007-06-11 Impact factor: 29.690
Authors: Manuel Martínez-Sellés; José A García Robles; Luis Prieto; Marta Domínguez Muñoa; Elisa Frades; Oscar Díaz-Castro; Jesus Almendral Journal: Eur Heart J Date: 2003-11 Impact factor: 29.983