Literature DB >> 29774537

When muscle doesn't 'Rac' it up, adipose tissue 'AKTs'.

Stephan van Vliet1, Bettina Mittendorfer1.   

Abstract

Entities:  

Keywords:  insulin resistance; insulin signaling; obesity

Mesh：

Substances：

Year:  2018        PMID： 29774537      PMCID： PMC6002216          DOI： 10.1113/JP276179

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  6 in total

1.  Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.

Authors:  Y B Kim; S E Nikoulina; T P Ciaraldi; R R Henry; B B Kahn
Journal:  J Clin Invest       Date:  1999-09       Impact factor: 14.808

Review 2.  Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action.

Authors:  Javier R Jaldin-Fincati; Martin Pavarotti; Scott Frendo-Cumbo; Philip J Bilan; Amira Klip
Journal:  Trends Endocrinol Metab       Date:  2017-06-08       Impact factor: 12.015

3.  Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.

Authors:  Young-Bum Kim; Ko Kotani; Theodore P Ciaraldi; Robert R Henry; Barbara B Kahn
Journal:  Diabetes       Date:  2003-08       Impact factor: 9.461

4.  Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects.

Authors:  K T Tonks; Y Ng; S Miller; A C F Coster; D Samocha-Bonet; T J Iseli; A Xu; E Patrick; J Y H Yang; J R Junutula; Z Modrusan; G Kolumam; J Stöckli; D J Chisholm; D E James; J R Greenfield
Journal:  Diabetologia       Date:  2013-01-24       Impact factor: 10.122

5.  Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.

Authors:  Steffen H Raun; Mona Ali; Rasmus Kjøbsted; Lisbeth L V Møller; Morten A Federspiel; Erik A Richter; Thomas E Jensen; Lykke Sylow
Journal:  J Physiol       Date:  2018-05-10       Impact factor: 5.182

6.  Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle.

Authors:  Lykke Sylow; Thomas E Jensen; Maximilian Kleinert; Kurt Højlund; Bente Kiens; Jørgen Wojtaszewski; Clara Prats; Peter Schjerling; Erik A Richter
Journal:  Diabetes       Date:  2013-02-19       Impact factor: 9.461
  6 in total

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