| Literature DB >> 29772303 |
Qiong Jin1, Dong Yang2, Zhi Dai2, Afsar Khan3, Bei Wang4, Xin Wei4, Ying Sun5, Yun-Li Zhao6, Yi-Fen Wang6, Ya-Ping Liu6, Xu-Dong Zhao7, Xiao-Dong Luo8.
Abstract
Nine new isoquinoline alkaloids, including two proaporphine (1-2), three aporphine (3-5), two oxoaporphine (6-7), and two seco-bisbenzylisoquinoline (8-9), together with three known alkaloids (10-12) were isolated from the whole plant of Thalictrum wangii. Their structures were established on the basis of spectroscopic data. The antitumor activities of the isolated compounds were evaluated in vitro against glioma stem cells. Compounds 3-8 showed the cytotoxicity with IC50 values 15-20 μg/mL.Entities:
Keywords: Antitumor; Aporphine alkaloids; Glioma stem cells; Thalictrum wangii
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Year: 2018 PMID： 29772303 DOI： 10.1016/j.fitote.2018.05.012
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882