Jasna Klen1, Katja Goričar2, Andrej Janež3, Vita Dolžan2. 1. General Hospital Trbovlje, Rudarska cesta 9, 1420 Trbovlje, Slovenia. 2. Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. 3. Department of Endocrinology, Diabetes & Metabolic Diseases, University Medical Center Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia.
Abstract
AIM: To investigate if antioxidative genes' polymorphisms influence the risk for Type 2 diabetes (T2D) complications. MATERIALS & METHODS: In total, 181 T2D patients were genotyped for SOD2, CAT, GPX1, GSTP1, GSTM1*0, GSTT1*0, GCLC and GCLM. RESULTS: After adjustment for duration of T2D, CAT rs1001179 and GSTP1 rs1138272 showed strongest association with risk for end-stage kidney failure (p = 0.005 and p = 0.049, respectively). In patients without end-stage kidney failure CAT rs1001179 influenced urea levels (p = 0.003), while GSTP1 rs1695 and GSTP1 haplotypes influenced the risk of moderately increased albuminuria (p = 0.024 and p = 0.014, respectively). CONCLUSION: Common CAT and GSTP1 polymorphisms could be used to identify T2D patients at an increased risk for developing end-stage kidney failure.
AIM: To investigate if antioxidative genes' polymorphisms influence the risk for Type 2 diabetes (T2D) complications. MATERIALS & METHODS: In total, 181 T2D patients were genotyped for SOD2, CAT, GPX1, GSTP1, GSTM1*0, GSTT1*0, GCLC and GCLM. RESULTS: After adjustment for duration of T2D, CATrs1001179 and GSTP1rs1138272 showed strongest association with risk for end-stage kidney failure (p = 0.005 and p = 0.049, respectively). In patients without end-stage kidney failureCATrs1001179 influenced urea levels (p = 0.003), while GSTP1rs1695 and GSTP1 haplotypes influenced the risk of moderately increased albuminuria (p = 0.024 and p = 0.014, respectively). CONCLUSION: Common CAT and GSTP1 polymorphisms could be used to identify T2D patients at an increased risk for developing end-stage kidney failure.