Literature DB >> 29771277

Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Matthew M Ippolito1,2,3, Jeffrey M Jacobson4, Michael M Lederman5, Markus Winterberg6,7, Joel Tarning6,7, Theresa A Shapiro1,3, Charles Flexner1,2.   

Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

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Year:  2018        PMID： 29771277      PMCID： PMC6206114          DOI： 10.1093/cid/ciy405

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  13 in total

1.  Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans.

Authors:  Stéphane Mouly; Kenneth S Lown; David Kornhauser; Jeffrey L Joseph; William D Fiske; Irma H Benedek; Paul B Watkins
Journal:  Clin Pharmacol Ther       Date:  2002-07       Impact factor: 6.875

Review 2.  Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.

Authors:  J Ducharme; R Farinotti
Journal:  Clin Pharmacokinet       Date:  1996-10       Impact factor: 6.447

3.  Return of chloroquine antimalarial efficacy in Malawi.

Authors:  Miriam K Laufer; Phillip C Thesing; Nicole D Eddington; Rhoda Masonga; Fraction K Dzinjalamala; Shannon L Takala; Terrie E Taylor; Christopher V Plowe
Journal:  N Engl J Med       Date:  2006-11-09       Impact factor: 91.245

4.  In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19.

Authors:  Cong Xu; Zeruesenay Desta
Journal:  Drug Metab Pharmacokinet       Date:  2013-02-05       Impact factor: 3.614

5.  CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.

Authors:  F Josephson; L Bertilsson; Y Böttiger; L Flamholc; M Gisslén; V Ormaasen; A Sönnerborg; U Diczfalusy
Journal:  Eur J Clin Pharmacol       Date:  2008-05-06       Impact factor: 2.953

6.  The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects.

Authors:  M Frisk-Holmberg; Y Bergqvist; E Termond; B Domeij-Nyberg
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

7.  In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

Authors:  Denis Projean; Bruno Baune; Robert Farinotti; Jean-Pierre Flinois; Philippe Beaune; Anne-Marie Taburet; Julie Ducharme
Journal:  Drug Metab Dispos       Date:  2003-06       Impact factor: 3.922

8.  In vitro assessment of the antimalarial activity of chloroquine and its major metabolites.

Authors:  A F Aderounmu
Journal:  Ann Trop Med Parasitol       Date:  1984-12

Review 9.  Global Epidemiology of Plasmodium vivax.

Authors:  Rosalind E Howes; Katherine E Battle; Kamini N Mendis; David L Smith; Richard E Cibulskis; J Kevin Baird; Simon I Hay
Journal:  Am J Trop Med Hyg       Date:  2016-07-11       Impact factor: 2.345

10.  Development of an evidence evaluation and synthesis system for drug-drug interactions, and its application to a systematic review of HIV and malaria co-infection.

Authors:  Kay Seden; Sara Gibbons; Catia Marzolini; Jonathan M Schapiro; David M Burger; David J Back; Saye H Khoo
Journal:  PLoS One       Date:  2017-03-23       Impact factor: 3.240
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  2 in total

1.  Dose Optimization of Hydroxychloroquine for Coronavirus Infection 2019: Do Blood Concentrations Matter?

Authors:  Matthew M Ippolito; Charles Flexner
Journal:  Clin Infect Dis       Date:  2020-12-31       Impact factor: 9.079

2.  The Anopheles coluzzii microbiome and its interaction with the intracellular parasite Wolbachia.

Authors:  Timothy J Straub; W Robert Shaw; Perrine Marcenac; Simon P Sawadogo; Roch K Dabiré; Abdoulaye Diabaté; Flaminia Catteruccia; Daniel E Neafsey
Journal:  Sci Rep       Date:  2020-08-14       Impact factor: 4.379
  2 in total

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