| Literature DB >> 29771234 |
Edson Delatorre1, Milene Miranda2,3,4, Diogo A Tschoeke4,2,5, Patrícia Carvalho de Sequeira6, Simone Alves Sampaio6, Giselle Barbosa-Lima7,8,9, Yasmine Rangel Vieira7,8,9, Luciana Leomil4,2, Fernando A Bozza7,8, José Cerbino-Neto7, Patricia T Bozza8, Rita Maria Ribeiro Nogueira6, Patrícia Brasil7, Fabiano L Thompson4,2, Ana M B de Filippis6, Thiago Moreno L Souza8,7,9.
Abstract
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).Entities:
Keywords: Brazil; Rio de Janeiro; Zika virus; neurological disease; neurotropism; zika
Mesh：
Substances：
Year: 2018 PMID： 29771234 DOI： 10.1099/jgv.0.001080
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891