Ruben Jauregui1,2,3, Karen Sophia Park1,2, Alexander G Bassuk4, Vinit B Mahajan5,6, Stephen H Tsang7,8,9,10. 1. Department of Ophthalmology, Columbia University, New York, NY, USA. 2. Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, New York, NY, USA. 3. Weill Cornell Medical College, New York, NY, USA. 4. Department of Pediatrics, University of Iowa, Iowa City, IA, USA. 5. Byers Eye Institute, Omics Laboratory, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA. 6. Palo Alto Veterans Administration, Palo Alto, CA, USA. 7. Department of Ophthalmology, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu. 8. Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, New York, NY, USA. sht2@cumc.columbia.edu. 9. Department of Pathology and Cell Biology, Stem Cell Initiative (CSCI), Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu. 10. Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY, 10032, USA. sht2@cumc.columbia.edu.
Abstract
PURPOSE: To report a case of deferoxamine-induced retinopathy characterized by electroretinography (ERG), optical coherence tomography angiography (OCT-A), and other multimodal imaging. METHODS: This is an observational case report of one patient. Full-field ERG was performed. OCT-A, spectral-domain optical coherence tomography (SD-OCT), color fundus photography, and fundus autofluorescence were used to characterize the retinopathy induced by deferoxamine use. RESULTS: A 64-year-old man with a history of β-thalassemia intermedia presented with worsening visual acuity, nyctalopia, and electronegative ERG. OCT-A revealed atrophy of the choriocapillaris in areas of hypoautofluorescence, corresponding to regions of retinal atrophy. SD-OCT showed disruption of the ellipsoid zone, granular hyperreflective deposits within the retinal pigment epithelium, thinning of the retinal layers, and extensive choroidal sclerosis and atrophy of the retinal pigment epithelium. CONCLUSION: Deferoxamine-induced retinopathy can manifest with electronegative maximal ERG responses, and OCT-A can be used to detect deferoxamine toxicity.
PURPOSE: To report a case of deferoxamine-induced retinopathy characterized by electroretinography (ERG), optical coherence tomography angiography (OCT-A), and other multimodal imaging. METHODS: This is an observational case report of one patient. Full-field ERG was performed. OCT-A, spectral-domain optical coherence tomography (SD-OCT), color fundus photography, and fundus autofluorescence were used to characterize the retinopathy induced by deferoxamine use. RESULTS: A 64-year-old man with a history of β-thalassemia intermedia presented with worsening visual acuity, nyctalopia, and electronegative ERG. OCT-A revealed atrophy of the choriocapillaris in areas of hypoautofluorescence, corresponding to regions of retinal atrophy. SD-OCT showed disruption of the ellipsoid zone, granular hyperreflective deposits within the retinal pigment epithelium, thinning of the retinal layers, and extensive choroidal sclerosis and atrophy of the retinal pigment epithelium. CONCLUSION:Deferoxamine-induced retinopathy can manifest with electronegative maximal ERG responses, and OCT-A can be used to detect deferoxaminetoxicity.
Authors: Francesco Viola; Giulio Barteselli; Laura Dell'arti; Diego Vezzola; Edoardo Villani; Chiara Mapelli; Laura Zanaboni; Maria D Cappellini; Roberto Ratiglia Journal: Ophthalmology Date: 2012-04-04 Impact factor: 12.079
Authors: Marion R Munk; Helena Giannakaki-Zimmermann; Lieselotte Berger; Wolfgang Huf; Andreas Ebneter; Sebastian Wolf; Martin S Zinkernagel Journal: PLoS One Date: 2017-05-10 Impact factor: 3.240