Yahya Ghazwani1, Ibrahim Qaddoumi1, Johnnie K Bass2, Shengjie Wu3, Jason Chiang4, Frederick Boop5,6,7,8, Amar Gajjar1, Zsila Sadighi9. 1. Department of Oncology, St. Jude Children's Research Hospital, USA. 2. Rehabilitation Services, St. Jude Children's Research Hospital, USA. 3. Department of Biostatistics, St. Jude Children's Research Hospital, USA. 4. Department of Pathology, St Jude Children's Research Hospital, USA. 5. Department of Neurosurgery, University of Tennessee Health Science Center, USA. 6. Le Bonheur Neuroscience Institute, Le Bonheur Children's Hospital, USA. 7. Semmes Murphey Neurologic and Spine Institute, USA. 8. Division of Neurosurgery, St Jude Children's Research Hospital, USA. 9. Department of Pediatric Medicine, Division of Neurology, St. Jude Children's Research Hospital, USA.
Abstract
BACKGROUND: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. METHODS: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology. RESULTS: Of the 115 patients, 15 (13.0%: 11 male, 6 black, 8 white, 1 multiracial; median age 7 years [range, 1.3-17.2 years]) had profound UHL after surgery alone or before receiving ototoxic therapy. Median age at tumor diagnosis was 6.8 years (range, 0.7-14.1 years), and median age at surgery was 6.8 years (range, 0.7-14.1 years). Patients with UHL had pathology characteristic of pilocytic astrocytoma (n = 10), ganglioglioma (n = 4), or low-grade astrocytoma (n = 1). Of these 15 patients, 4 underwent biopsy, 1 underwent gross total resection, 1 underwent near-total resection, and 9 underwent subtotal resection. UHL was more frequent in black patients than in white patients (OR 7.3, P = .007) and less frequent in patients who underwent gross total resection or near-total resection than in those who underwent subtotal resection (OR 0.11, P = .02). CONCLUSIONS: Children undergoing surgery for posterior fossa low-grade glioma are at risk for UHL, which may be related to race or extent of resection. These patients should receive postoperative audiologic testing, as earlier intervention may improve outcomes.
BACKGROUND: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. METHODS: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology. RESULTS: Of the 115 patients, 15 (13.0%: 11 male, 6 black, 8 white, 1 multiracial; median age 7 years [range, 1.3-17.2 years]) had profound UHL after surgery alone or before receiving ototoxic therapy. Median age at tumor diagnosis was 6.8 years (range, 0.7-14.1 years), and median age at surgery was 6.8 years (range, 0.7-14.1 years). Patients with UHL had pathology characteristic of pilocytic astrocytoma (n = 10), ganglioglioma (n = 4), or low-grade astrocytoma (n = 1). Of these 15 patients, 4 underwent biopsy, 1 underwent gross total resection, 1 underwent near-total resection, and 9 underwent subtotal resection. UHL was more frequent in black patients than in white patients (OR 7.3, P = .007) and less frequent in patients who underwent gross total resection or near-total resection than in those who underwent subtotal resection (OR 0.11, P = .02). CONCLUSIONS: Children undergoing surgery for posterior fossa low-grade glioma are at risk for UHL, which may be related to race or extent of resection. These patients should receive postoperative audiologic testing, as earlier intervention may improve outcomes.
Entities:
Keywords:
hearing loss; low-grade glioma; pediatric; posterior fossa; surgery
Authors: Kimberly Whelan; Kayla Stratton; Toana Kawashima; Wendy Leisenring; Susan Hayashi; John Waterbor; Julie Blatt; Charles A Sklar; Roger Packer; Pauline Mitby; Leslie L Robison; Ann C Mertens Journal: Pediatr Blood Cancer Date: 2011-02-15 Impact factor: 3.167
Authors: R J Packer; J Ater; J Allen; P Phillips; R Geyer; H S Nicholson; R Jakacki; E Kurczynski; M Needle; J Finlay; G Reaman; J M Boyett Journal: J Neurosurg Date: 1997-05 Impact factor: 5.115
Authors: P Pencalet; W Maixner; C Sainte-Rose; A Lellouch-Tubiana; G Cinalli; M Zerah; A Pierre-Kahn; E Hoppe-Hirsch; M Bourgeois; D Renier Journal: J Neurosurg Date: 1999-02 Impact factor: 5.115
Authors: Dennis J Kuo; Howard L Weiner; Jeffrey Wisoff; Douglas C Miller; Edmond A Knopp; Jonathan L Finlay Journal: J Pediatr Hematol Oncol Date: 2003-05 Impact factor: 1.289
Authors: Pratiti Bandopadhayay; Guillaume Bergthold; Wendy B London; Liliana C Goumnerova; Andres Morales La Madrid; Karen J Marcus; Dongjing Guo; Nicole J Ullrich; Nathan J Robison; Susan N Chi; Rameen Beroukhim; Mark W Kieran; Peter E Manley Journal: Pediatr Blood Cancer Date: 2014-01-30 Impact factor: 3.167
Authors: Anthony P Y Liu; Camden Hastings; Shengjie Wu; Johnnie K Bass; Andrew M Heitzer; Jason Ashford; Robert Vestal; Mary E Hoehn; Yahya Ghazwani; Sahaja Acharya; Heather M Conklin; Frederick Boop; Thomas E Merchant; Amar Gajjar; Ibrahim Qaddoumi Journal: Cancer Date: 2019-01-08 Impact factor: 6.860