Literature DB >> 29769951

A new diagnostic test for Creutzfeldt-Jakob disease: Real-time quaking-induced conversion (RT-QulC).

D Godal1, Slr Simon1, K Cheng1,2, J D Knox1,3.   

Abstract

Currently, definitive diagnoses of Creutzfeldt-Jakob disease (CJD) require an examination of the brains of deceased patients. In cooperation with an international consortium, Canada's National Microbiology Laboratory is performing a validation of a new test that can diagnose CJD in living patients. This test, the real-time quaking-induced conversion (RT-QuIC) assay, directly detects the disease associated form of the prion protein in cerebrospinal fluid. If validated, RT-QuIC will represent a major advance in the diagnoses of patients suspected to have CJD.

Entities:  

Year:  2015        PMID： 29769951      PMCID： PMC5864299          DOI： 10.14745/ccdr.v41i08a02

Source DB:  PubMed          Journal:  Can Commun Dis Rep        ISSN： 1188-4169


  15 in total

1.  Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding.

Authors:  G P Saborio; B Permanne; C Soto
Journal:  Nature       Date:  2001-06-14       Impact factor: 49.962

2.  Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein.

Authors:  Ryuichiro Atarashi; Roger A Moore; Valerie L Sim; Andrew G Hughson; David W Dorward; Henry A Onwubiko; Suzette A Priola; Byron Caughey
Journal:  Nat Methods       Date:  2007-07-22       Impact factor: 28.547

3.  Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.

Authors:  Ryuichiro Atarashi; Katsuya Satoh; Kazunori Sano; Takayuki Fuse; Naohiro Yamaguchi; Daisuke Ishibashi; Takehiro Matsubara; Takehiro Nakagaki; Hitoki Yamanaka; Susumu Shirabe; Masahito Yamada; Hidehiro Mizusawa; Tetsuyuki Kitamoto; Genevieve Klug; Amelia McGlade; Steven J Collins; Noriyuki Nishida
Journal:  Nat Med       Date:  2011-01-30       Impact factor: 53.440

4.  Genetic prion disease: the EUROCJD experience.

Authors:  Gábor G Kovács; Maria Puopolo; Anna Ladogana; Maurizio Pocchiari; Herbert Budka; Cornelia van Duijn; Steven J Collins; Alison Boyd; Antonio Giulivi; Mike Coulthart; Nicole Delasnerie-Laupretre; Jean Philippe Brandel; Inga Zerr; Hans A Kretzschmar; Jesus de Pedro-Cuesta; Miguel Calero-Lara; Markus Glatzel; Adriano Aguzzi; Matthew Bishop; Richard Knight; Girma Belay; Robert Will; Eva Mitrova
Journal:  Hum Genet       Date:  2005-11-15       Impact factor: 4.132

5.  A test for Creutzfeldt-Jakob disease using nasal brushings.

Authors:  Christina D Orrú; Matilde Bongianni; Giovanni Tonoli; Sergio Ferrari; Andrew G Hughson; Bradley R Groveman; Michele Fiorini; Maurizio Pocchiari; Salvatore Monaco; Byron Caughey; Gianluigi Zanusso
Journal:  N Engl J Med       Date:  2014-08-07       Impact factor: 91.245

6.  Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

Authors:  Jason M Wilham; Christina D Orrú; Richard A Bessen; Ryuichiro Atarashi; Kazunori Sano; Brent Race; Kimberly D Meade-White; Lara M Taubner; Andrew Timmes; Byron Caughey
Journal:  PLoS Pathog       Date:  2010-12-02       Impact factor: 6.823

7.  Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion.

Authors:  Alexander H Peden; Lynne I McGuire; Nigel E J Appleford; Gary Mallinson; Jason M Wilham; Christina D Orrú; Byron Caughey; James W Ironside; Richard S Knight; Robert G Will; Alison J E Green; Mark W Head
Journal:  J Gen Virol       Date:  2011-10-26       Impact factor: 3.891

8.  Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study.

Authors:  Michael B Coulthart; Gerard H Jansen; Elina Olsen; Deborah L Godal; Tim Connolly; Bernard C K Choi; Zheng Wang; Neil R Cashman
Journal:  BMC Neurol       Date:  2011-10-27       Impact factor: 2.474

9.  Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay.

Authors:  Keding Cheng; Angela Sloan; Kristen M Avery; Michael Coulthart; Michael Carpenter; J David Knox
Journal:  PLoS One       Date:  2014-01-03       Impact factor: 3.240

10.  Creutzfeldt-Jakob disease mortality in Canada, 1998 to 2013.

Authors:  M B Coulthart; G H Jansen; T Connolly; R D'Amour; J Kruse; J Lynch; S Sabourin; Z Wang; A Giulivi; M N Ricketts; N R Cashman
Journal:  Can Commun Dis Rep       Date:  2015-08-06
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  1 in total

1.  Clinical manifestations and polysomnography-based analysis in nine cases of probable sporadic Creutzfeldt-Jakob disease.

Authors:  Yanyuan Dai; Jie Shao; Yue Lang; Yudan Lv; Li Cui
Journal:  Neurol Sci       Date:  2021-02-08       Impact factor: 3.307
  1 in total

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