Gender differences in hemostatic and inflammatory factors in patients with acute coronary syndromes: a pilot study.

Many studies have shown gender differences in the progress of acute coronary syndromes (ACS). These differences include, amongst others, processes involved in hemostasis and inflammation, and in the present study we put forward the hypothesis that these are the primary cause of other differences. The study included 66 ACS patients (27 women and 39 men) aged 43 - 83 years, 23 with non-ST-elevation myocardial infarction (NSTEMI) and 43 with ST-elevation myocardial infarction (STEMI). Blood samples were taken on day 3 (NSTEMI) or day 5 (STEMI) after hospitalization, and fibrinogen, D-dimers, von Willebrand factor, C-reactive protein and interleukin-6 levels measured. Men, compared to women, had significantly higher levels of fibrinogen (STEMI: P = 0.028; NSTEMI: P = 0.008), C-reactive protein (STEMI: P <0.0001; NSTEMI: P = 0.004) and interleukin-6 with STEMI (P = 0.015), but a lower D-dimer concentration with NSTEMI (P = 0.042). In women fibrinogen concentration was significantly higher with STEMI compared to NSTEMI (P = 0.052). Significant correlations were found between hemostatic and proinflammatory factors, especially in men, regardless of ACS type. In addition, correlations between fibrinogen and D-dimers were found: negative for women (r = -0.67) ) and positive for men (r = +0.60), as was that between C-reactive protein and interleukin-6: women (r = -0.72); men (r = +0.56). Based on these findings, we conclude that acute coronary syndromes in men may be potentially related to inflammatory processes, as indicated by strong associations between elevated C-reactive protein, interleukin-6 and hyperfibrinogenemia, most clearly shown in STEMI. By contrast in women, factors possibly most important for the course of acute coronary syndrome are D-dimer concentrations and an increased turnover of fibrin with NSTEMI and hyperfibrinogenemia with STEMI.