Pauline H Croll1, Trudy Voortman1, M Arfan Ikram1, Oscar H Franco1, Josje D Schoufour1, Daniel Bos1, Meike W Vernooij2. 1. From the Departments of Epidemiology (P.H.C., T.V., M.A.I., O.H.F., J.D.S., D.B., M.W.V.) and Radiology and Nuclear Medicine (P.H.C., D.B., M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands. 2. From the Departments of Epidemiology (P.H.C., T.V., M.A.I., O.H.F., J.D.S., D.B., M.W.V.) and Radiology and Nuclear Medicine (P.H.C., D.B., M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands. m.vernooij@erasmusmc.nl.
Abstract
OBJECTIVE: To investigate the relation of diet quality with structural brain tissue volumes and focal vascular lesions in a dementia-free population. METHODS: From the population-based Rotterdam Study, 4,447 participants underwent dietary assessment and brain MRI scanning between 2005 and 2015. We excluded participants with an implausible energy intake, prevalent dementia, or cortical infarcts, leaving 4,213 participants for the current analysis. A diet quality score (0-14) was calculated reflecting adherence to Dutch dietary guidelines. Brain MRI was performed to obtain information on brain tissue volumes, white matter lesion volume, lacunes, and cerebral microbleeds. The associations of diet quality score and separate food groups with brain structures were assessed using multivariable linear and logistic regression. RESULTS: We found that better diet quality related to larger brain volume, gray matter volume, white matter volume, and hippocampal volume. Diet quality was not associated with white matter lesion volume, lacunes, or microbleeds. High intake of vegetables, fruit, whole grains, nuts, dairy, and fish and low intake of sugar-containing beverages were associated with larger brain volumes. CONCLUSIONS: A better diet quality is associated with larger brain tissue volumes. These results suggest that the effect of nutrition on neurodegeneration may act via brain structure. More research, in particular longitudinal research, is needed to unravel direct vs indirect effects between diet quality and brain health.
OBJECTIVE: To investigate the relation of diet quality with structural brain tissue volumes and focal vascular lesions in a dementia-free population. METHODS: From the population-based Rotterdam Study, 4,447 participants underwent dietary assessment and brain MRI scanning between 2005 and 2015. We excluded participants with an implausible energy intake, prevalent dementia, or cortical infarcts, leaving 4,213 participants for the current analysis. A diet quality score (0-14) was calculated reflecting adherence to Dutch dietary guidelines. Brain MRI was performed to obtain information on brain tissue volumes, white matter lesion volume, lacunes, and cerebral microbleeds. The associations of diet quality score and separate food groups with brain structures were assessed using multivariable linear and logistic regression. RESULTS: We found that better diet quality related to larger brain volume, gray matter volume, white matter volume, and hippocampal volume. Diet quality was not associated with white matter lesion volume, lacunes, or microbleeds. High intake of vegetables, fruit, whole grains, nuts, dairy, and fish and low intake of sugar-containing beverages were associated with larger brain volumes. CONCLUSIONS: A better diet quality is associated with larger brain tissue volumes. These results suggest that the effect of nutrition on neurodegeneration may act via brain structure. More research, in particular longitudinal research, is needed to unravel direct vs indirect effects between diet quality and brain health.
Authors: Sarah U Morton; Brian J Leyshon; Eleonora Tamilia; Rutvi Vyas; Michaela Sisitsky; Imran Ladha; John B Lasekan; Matthew J Kuchan; P Ellen Grant; Yangming Ou Journal: Front Psychiatry Date: 2022-06-23 Impact factor: 5.435
Authors: Sabrina Salberg; Glenn R Yamakawa; Yannick Griep; Jesse Bain; Jaimie K Beveridge; Mujun Sun; Stuart J McDonald; Sandy R Shultz; Rhys D Brady; David K Wright; Melanie Noel; Richelle Mychasiuk Journal: Cereb Cortex Commun Date: 2021-02-24
Authors: Wolfgang Marx; Melissa Lane; Meghan Hockey; Hajara Aslam; Michael Berk; Ken Walder; Alessandra Borsini; Joseph Firth; Carmine M Pariante; Kirsten Berding; John F Cryan; Gerard Clarke; Jeffrey M Craig; Kuan-Pin Su; David Mischoulon; Fernando Gomez-Pinilla; Jane A Foster; Patrice D Cani; Sandrine Thuret; Heidi M Staudacher; Almudena Sánchez-Villegas; Husnain Arshad; Tasnime Akbaraly; Adrienne O'Neil; Toby Segasby; Felice N Jacka Journal: Mol Psychiatry Date: 2020-11-03 Impact factor: 15.992
Authors: Leah H Rubin; Deborah R Gustafson; Lakshmi Warrior; Lila Sheira; Kathryn C Fitzgerald; Raha Dastgheyb; Kathleen M Weber; Phyllis C Tien; Audrey French; Amanda B Spence; Anjali Sharma; Dionna W Williams; Cory J White; Eric C Seaberg; Edward A Frongillo; Sheri D Weiser Journal: Am J Clin Nutr Date: 2021-07-01 Impact factor: 8.472
Authors: Pauline H Croll; Daniel Bos; Mohammad Arfan Ikram; Fernando Rivadeneira; Trudy Voortman; Meike W Vernooij Journal: Front Neurol Date: 2019-05-28 Impact factor: 4.003
Authors: M Arfan Ikram; Guy Brusselle; Mohsen Ghanbari; André Goedegebure; M Kamran Ikram; Maryam Kavousi; Brenda C T Kieboom; Caroline C W Klaver; Robert J de Knegt; Annemarie I Luik; Tamar E C Nijsten; Robin P Peeters; Frank J A van Rooij; Bruno H Stricker; André G Uitterlinden; Meike W Vernooij; Trudy Voortman Journal: Eur J Epidemiol Date: 2020-05-04 Impact factor: 8.082
Authors: Jennifer L Dearborn-Tomazos; Aozhou Wu; Lyn M Steffen; Cheryl A M Anderson; Emily A Hu; David Knopman; Thomas H Mosley; Rebecca F Gottesman Journal: JAMA Netw Open Date: 2019-12-02