Playing the Melanoma Endgame.

Treatments for melanoma are of two main types: targeted therapies and immune checkpoint inhibitors. However, both are effective in only a subset of patients and are limited by acquired resistance. Here, the authors present the preclinical basis to broadly target different forms of therapy-resistant melanoma. Clin Cancer Res; 24(19); 4629-30. ©2018 AACR See related article by Zhang et al., p. 4771. ©2018 American Association for Cancer Research.