Yusuf Kenan Daglioglu1, Ozgul Duzgun2, Inanc Samil Sarici3, Kemal Turker Ulutas4. 1. Associate Professor, Department of Experimental Medical Research and Application Center, Faculty of Medicine, Cukurova University, Adana, Turkey. Critical revision. 2. MD, Department of Surgical Oncology, Umraniye Training and Research Hospital, Istanbul, Turkey. Conception, design, scientific, and intellectual content of the study; technical procedures. 3. MD, Department of General Surgery, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey. Statistical analysis, manuscript writing, final approval. 4. MD, Department of Clinical Biochemistry, Kadirli State Hospital, Osmaniye, Turkey. Interpretation of data, critical revision.
Abstract
PURPOSE: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. METHODS: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days. RESULTS: There was no statistically significant difference of the ABP and hydroxyproline levels between PRP and fibrin glue on the 7th day. There was no statistically significant difference between levels of proinflammatory cytokine (IL-6) (P=0.41), anti-inflammatory cytokine (IL-10) (P=0.35), and procalcitonin levels (P=0.63) on 1, 3 and 7 days. CONCLUSION: Fibrin glue and platelet rich plasma are shown to be effective in healing intestinal anastomoses without superior to each other.
PURPOSE: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. METHODS: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days. RESULTS: There was no statistically significant difference of the ABP and hydroxyproline levels between PRP and fibrin glue on the 7th day. There was no statistically significant difference between levels of proinflammatory cytokine (IL-6) (P=0.41), anti-inflammatory cytokine (IL-10) (P=0.35), and procalcitonin levels (P=0.63) on 1, 3 and 7 days. CONCLUSION: Fibrin glue and platelet rich plasma are shown to be effective in healing intestinal anastomoses without superior to each other.
Authors: Hasan Cantay; Ugur Aydin; Isa Ozaydin; Turgut Anuk; Serap Koral Tasci; Ugur Yildiz; Dilem Ermutlu; Ozgur Aksoy Journal: Arq Bras Cir Dig Date: 2022-06-24
Authors: Mehmet Akif Aydin; Eray Metin Guler; Ahu Senem Demiroz; Muhammet Fatih Aydin; Gulcan Saglam Journal: Gastroenterol Res Pract Date: 2020-05-26 Impact factor: 2.260