Literature DB >> 29768173

Peek-Peak-Pique: Repeating Motifs of Subtle Variance Are Targets for Potent Malaria Antibodies.

Stephen W Scally1, Jean-Philippe Julien2.   

Abstract

Biomedical interventions to curb malaria-causing Plasmodium falciparum (Pf) infections are critically needed. Two studies in Nature Medicine,Kisalu et al. (2018) and Tan et al. (2018), report the isolation of potent human antibodies that target a new epitope on Pf sporozoites and mediate effective parasite inhibition in pre-clinical models.
Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29768173     DOI： 10.1016/j.immuni.2018.04.037

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  5 in total

1.  A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Authors:  Lawrence T Wang; Lais S Pereira; Yevel Flores-Garcia; James O'Connor; Barbara J Flynn; Arne Schön; Nicholas K Hurlburt; Marlon Dillon; Annie S P Yang; Amanda Fabra-García; Azza H Idris; Bryan T Mayer; Monica W Gerber; Raphael Gottardo; Rosemarie D Mason; Nicole Cavett; Reid B Ballard; Neville K Kisalu; Alvaro Molina-Cruz; Jorgen Nelson; Rachel Vistein; Carolina Barillas-Mury; Rogerio Amino; David Baker; Neil P King; Robert W Sauerwein; Marie Pancera; Ian A Cockburn; Fidel Zavala; Joseph R Francica; Robert A Seder
Journal:  Immunity       Date:  2020-09-17       Impact factor: 31.745

Review 2.  Plasmodium falciparum pre-erythrocytic stage vaccine development.

Authors:  Jessica Molina-Franky; Laura Cuy-Chaparro; Anny Camargo; César Reyes; Marcela Gómez; David Ricardo Salamanca; Manuel Alfonso Patarroyo; Manuel Elkin Patarroyo
Journal:  Malar J       Date:  2020-02-03       Impact factor: 2.979

3.  Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11.

Authors:  Iga Kucharska; Elaine Thai; Ananya Srivastava; John L Rubinstein; Régis Pomès; Jean-Philippe Julien
Journal:  Elife       Date:  2020-11-30       Impact factor: 8.140

4.  Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats.

Authors:  Iga Kucharska; Lamia Hossain; Danton Ivanochko; Qiren Yang; John L Rubinstein; Régis Pomès; Jean-Philippe Julien
Journal:  Elife       Date:  2022-01-13       Impact factor: 8.140

5.  Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein.

Authors:  Lawrence T Wang; Lais S Pereira; Patience K Kiyuka; Arne Schön; Neville K Kisalu; Rachel Vistein; Marlon Dillon; Brian G Bonilla; Alvaro Molina-Cruz; Carolina Barillas-Mury; Joshua Tan; Azza H Idris; Joseph R Francica; Robert A Seder
Journal:  PLoS Pathog       Date:  2021-12-06       Impact factor: 6.823
  5 in total

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