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Literature DB >> 29768169

TREMendous 2 Be Social.

Narghes Calcagno¹, Caroline Baufeld¹, Charlotte Madore¹, Oleg Butovsky².

Abstract

TREM2 is known for its role in microglial phagocytosis and in neurodegenerative diseases. In this issue of Immunity, Filipello et al. (2018) show that microglial TREM2 is required for synaptic pruning in early development. TREM2-deficient mice show altered social behavior in adulthood, linking TREM2 to neurodevelopmental disease.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2018 PMID： 29768169 PMCID： PMC8152169 DOI： 10.1016/j.immuni.2018.04.034

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

10 in total

1. Synaptic pruning by microglia is necessary for normal brain development.

Authors: Rosa C Paolicelli; Giulia Bolasco; Francesca Pagani; Laura Maggi; Maria Scianni; Patrizia Panzanelli; Maurizio Giustetto; Tiago Alves Ferreira; Eva Guiducci; Laura Dumas; Davide Ragozzino; Cornelius T Gross
Journal: Science Date: 2011-07-21 Impact factor: 47.728

2. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

Authors: Tyler K Ulland; Wilbur M Song; Stanley Ching-Cheng Huang; Jason D Ulrich; Alexey Sergushichev; Wandy L Beatty; Alexander A Loboda; Yingyue Zhou; Nigel J Cairns; Amal Kambal; Ekaterina Loginicheva; Susan Gilfillan; Marina Cella; Herbert W Virgin; Emil R Unanue; Yaming Wang; Maxim N Artyomov; David M Holtzman; Marco Colonna
Journal: Cell Date: 2017-08-10 Impact factor: 41.582

Review 3. Elucidating the Role of TREM2 in Alzheimer's Disease.

Authors: Jason D Ulrich; Tyler K Ulland; Marco Colonna; David M Holtzman
Journal: Neuron Date: 2017-04-19 Impact factor: 17.173

4. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Authors: Susanne Krasemann; Charlotte Madore; Ron Cialic; Caroline Baufeld; Narghes Calcagno; Rachid El Fatimy; Lien Beckers; Elaine O'Loughlin; Yang Xu; Zain Fanek; David J Greco; Scott T Smith; George Tweet; Zachary Humulock; Tobias Zrzavy; Patricia Conde-Sanroman; Mar Gacias; Zhiping Weng; Hao Chen; Emily Tjon; Fargol Mazaheri; Kristin Hartmann; Asaf Madi; Jason D Ulrich; Markus Glatzel; Anna Worthmann; Joerg Heeren; Bogdan Budnik; Cynthia Lemere; Tsuneya Ikezu; Frank L Heppner; Vladimir Litvak; David M Holtzman; Hans Lassmann; Howard L Weiner; Jordi Ochando; Christian Haass; Oleg Butovsky
Journal: Immunity Date: 2017-09-19 Impact factor: 31.745

5. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.

Authors: Dorothy P Schafer; Emily K Lehrman; Amanda G Kautzman; Ryuta Koyama; Alan R Mardinly; Ryo Yamasaki; Richard M Ransohoff; Michael E Greenberg; Ben A Barres; Beth Stevens
Journal: Neuron Date: 2012-05-24 Impact factor: 17.173

Review 6. Microglia Function in the Central Nervous System During Health and Neurodegeneration.

Authors: Marco Colonna; Oleg Butovsky
Journal: Annu Rev Immunol Date: 2017-02-09 Impact factor: 28.527

7. The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.

Authors: Fabia Filipello; Raffaella Morini; Irene Corradini; Valerio Zerbi; Alice Canzi; Bernadeta Michalski; Marco Erreni; Marija Markicevic; Chiara Starvaggi-Cucuzza; Karel Otero; Laura Piccio; Francesca Cignarella; Fabio Perrucci; Matteo Tamborini; Marco Genua; Lawrence Rajendran; Elisabetta Menna; Stefania Vetrano; Margaret Fahnestock; Rosa Chiara Paolicelli; Michela Matteoli
Journal: Immunity Date: 2018-05-08 Impact factor: 31.745

8. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

Authors: Peng Yuan; Carlo Condello; C Dirk Keene; Yaming Wang; Thomas D Bird; Steven M Paul; Wenjie Luo; Marco Colonna; David Baddeley; Jaime Grutzendler
Journal: Neuron Date: 2016-05-18 Impact factor: 17.173

Review 9. A Short Review on the Current Understanding of Autism Spectrum Disorders.

Authors: Hye Ran Park; Jae Meen Lee; Hyo Eun Moon; Dong Soo Lee; Bung-Nyun Kim; Jinhyun Kim; Dong Gyu Kim; Sun Ha Paek
Journal: Exp Neurobiol Date: 2016-01-28 Impact factor: 3.261

10. TREM2 variants in Alzheimer's disease.

Authors: Rita Guerreiro; Aleksandra Wojtas; Jose Bras; Minerva Carrasquillo; Ekaterina Rogaeva; Elisa Majounie; Carlos Cruchaga; Celeste Sassi; John S K Kauwe; Steven Younkin; Lilinaz Hazrati; John Collinge; Jennifer Pocock; Tammaryn Lashley; Julie Williams; Jean-Charles Lambert; Philippe Amouyel; Alison Goate; Rosa Rademakers; Kevin Morgan; John Powell; Peter St George-Hyslop; Andrew Singleton; John Hardy
Journal: N Engl J Med Date: 2012-11-14 Impact factor: 91.245

10 in total

1 in total

1. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism.

Authors: Honghua Zheng; Baoying Cheng; Yanfang Li; Xin Li; Xiaofen Chen; Yun-Wu Zhang
Journal: Front Aging Neurosci Date: 2018-11-23 Impact factor: 5.750

1 in total