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Literature DB >> 29768006

Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor.

Qiong Yang¹, Guo-Li Dai¹, Yu-Ming Yang¹, Zhuangzhu Luo², Zhen-Yu Tang^1,2.

Abstract

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.

Entities: Chemical

Year: 2018 PMID： 29768006 DOI： 10.1021/acs.joc.8b00737

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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Cited

1 in total

1. Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor^®.

Authors: Nadiia V Pikun; Arkadij Sobolev; Aiva Plotniece; Martins Rucins; Brigita Vigante; Marina Petrova; Ruslan Muhamadejev; Karlis Pajuste; Yuriy G Shermolovich
Journal: Molecules Date: 2020-07-09 Impact factor: 4.411

1 in total

Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor.

1. Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor®.

1. Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor^®.