| Literature DB >> 29766099 |
Peter Andrawes1, Antonio I Picon1,2, Masood A Shariff1, Basem Azab1, Wolf von Waagner1, Seleshi Demissie3, Charles Fasanya1,4.
Abstract
BACKGROUND: CT scans are heavily relied on for assessment of solid organ injuries complementing clinical examination. These CT scans could also reveal pathologies not related to trauma called incidental findings. We aimed to evaluate the frequency of these findings and their outcome on hospital services.Entities:
Keywords: computed tomography scan; incidental findings; incidentaloma; trauma
Year: 2017 PMID: 29766099 PMCID: PMC5877912 DOI: 10.1136/tsaco-2017-000101
Source DB: PubMed Journal: Trauma Surg Acute Care Open ISSN: 2397-5776
Baseline characteristics and trauma-related outcomes
| Overall | Positive findings | Negative findings | p Value | |
| n=957 | n=385 | n=572 | ||
| Characteristics | ||||
| Age (years) | 54.3±27.6 | 62.0±22.3 | 49.2±29.5 | 0.0001 |
| Median (range) | 58 (<1–100) | 66.3 (<1–98) | 47 (<1–98) | |
| Elderly, ≥65 years | 424 (44.3) | 204 (53.0) | 220 (38.5) | |
| Gender | 0.2828 | |||
| Male | 572 (59.8) | 222 (57.7) | 350 (61.2) | |
| Female | 385 (40.2) | 163 (42.3) | 222 (38.8) | |
| Caucasian, race | 816 (85.3) | 335 (87.0) | 481 (84.1) | 0.2273 |
| Body mass index, kg/m2 | 25.9±6.6 | 26.6±9.4 | 26.2±8.8 | 0.5948 |
| Current smoker | 331 (34.6) | 136 (35.3) | 195 (34.1) | 0.7291 |
| Cardiopulmonary disease | 490 (51.2) | 224 (58.2) | 266 (46.5) | 0.0005 |
| Diabetes | 55 (5.7) | 24 (6.2) | 31 (5.4) | 0.6713 |
| Hypertension | 147 (15.4) | 60 (15.6) | 87 (15.2) | 0.9272 |
| Coronary artery disease | 34 (3.6) | 19 (4.9) | 15 (2.6) | 0.0740 |
| Pulmonary disease | 20 (2.1) | 10 (2.6) | 10 (1.7) | 0.3681 |
| Alcoholism | 14 (1.5) | 8 (2.1) | 6 (1) | 0.2717 |
| History of cancer | 85 (8.9) | 32 (8.3) | 53 (9.3) | 0.6445 |
| History of prior surgery | 443 (46.3) | 200 (51.9) | 243 (42.5) | 0.0045 |
| Trauma classification | ||||
| Fall | 551 (57.6) | 238 (61.8) | 313 (54.7) | 0.0328 |
| Motor vehicle accident | 217 (22.7) | 99 (25.7) | 118 (20.6) | 0.0704 |
| Pedestrian | 55 (5.7) | 22 (5.7) | 33 (5.8) | NS |
| Assault | 56 (5.9) | 16 (4.2) | 40 (7.0) | 0.0693 |
| Gunshot wound | 8 (0.8) | 1 (0.3) | 7 (1.2) | 0.1535 |
| Stab | 11 (1.1) | 0 | 11 (1.9) | 0.0041 |
| Other | 59 (6.2) | 9 (2.3) | 50 (8.7) | NS |
| Trauma type | 0.0124 | |||
| Blunt | 919 (96.0) | 378 (98.2) | 541 (94.6) | |
| Penetrating | 24 (2.5) | 3 (0.8) | 21 (3.7) | |
| Other | 14 (1.5) | 4 (1) | 10 (1.7) | |
| Injury severity score | 13.5±7.7 | 14.2±7.8 | 13.1±7.7 | 0.0325 |
| Median (range) | 10 (1–66) | 13 (1–50) | 10 (1–66) | |
| No. of CT scans | ||||
| Head | 813 (85.0) | 355 (92.2) | 458 (80.1) | 0.0001 |
| Chest | 390 (40.8) | 240 (62.3) | 150 (26.2) | 0.0001 |
| Abdomen and pelvis | 617 (64.5) | 356 (92.5) | 261 (45.6) | 0.0001 |
| All of the above | 336 (35.1) | 212 (55.1) | 124 (21.7) | 0.0001 |
| ICU admission required | 268 (28.0) | 133 (34.5) | 135 (23.6) | 0.0002 |
| Hospital length of stay | 7.3±10.1 | 8.7±12.8 | 6.4±7.7 | 0.0012 |
| Median (range) | 5 (1–175) | 6 (1–175) | 4 (1–96) | |
| Discharge disposition | <0.0001 | |||
| Home | 540 (56.4) | 187 (48.6) | 353 (61.7) | |
| Rehab unit | 191 (20.0) | 94 (24.4) | 97 (17.0) | |
| Death | 67 (7.0) | 37 (9.6) | 30 (5.2) | |
| Skilled nursing facility | 59 (6.2) | 30 (7.8) | 29 (5.1) | |
| Against medical advice | 15 (1.6) | 7 (1.8) | 8 (1.4) | |
| Psychiatric unit | 3 (0.3) | 3 (0.8) | 0 | |
| Other | 82 (8.6) | 27 (7.0) | 55 (9.6) |
Values are given as mean±SD with median and range for continuous, or n (%) for categorical.
ICU, intensive care unit; NS, no significance.
Incidental finding by classification
| Total incidental findings | 560 |
| Class 1 | 51 (9.1) |
| Sinus—polyp/cyst | 17 (3) |
| Bladder diverticulum | 7 (1.3) |
| Duodenal diverticulum | 5 (0.9) |
| Duplicate renal system | 4 (0.7) |
| Vertebral body | |
| Hemangioma | 4 (0.7) |
| Accessory spleen | 3 (0.5) |
| Horse shoe kidney | 3 (0.5) |
| Bovine aortic arch | 3 (0.5) |
| Left-sided superior vena cava | 2 (0.4) |
| Adrenal mylolipoma | 2 (0.4) |
| Undescended testicle | 1 (0.2) |
| Class 2 | 354 (63.2) |
| Renal | 104 (18.6) |
| Kidney cyst | 91 |
| Stone | 13 |
| Lung nodule | 70 (13) |
| Thyroid nodule | 39 (7) |
| Adrenal nodule | 36 (6.4) |
| Ovarian cyst | 20 (3.6) |
| Hepatic cyst | 19 (3.4) |
| Spleen | 14 (2.5) |
| Hemangiomas | 13 |
| Cyst | 1 |
| Hiatal hernia | 10 (1.8) |
| Hernia | 8 (1.4) |
| Inguinal | 6 |
| Umbilical | 2 |
| Dilated intrahepatic ducts | 5 (0.9) |
| Uterine fibroid | 5 (0.9) |
| Prostate enlargement | 4 (0.7) |
| Gall stones | 4 (0.7) |
| Skin lesions (lipoma) | 4 (0.7) |
| Arachnoid cyst | 3 (0.5) |
| Hydrocele | 3 (0.5) |
| Diaphragmatic hernia | 2 (0.4) |
| Pleural nodule | 2 (0.4) |
| Splenomegaly | 1 (0.2) |
| Small bowel lesion (lipoma) | 1 (0.2) |
| Class 3 | 155 (27.7) |
| Kidney hypodense lesions | 36 (6.4) |
| Liver hypodense lesions | 30 (5.4) |
| Pancreatic mass type | 30 (5.4) |
| Hypodense lesions | 15 |
| Cyst | 5 |
| Mediastinal lymph node | 14 (2.5) |
| Brain lesion | 11 (2) |
| Abdominal aortic | |
| Aneurysm | 11 (2) |
| Lung mass | 6 (1.1) |
| Breast | 5 (0.9) |
| Iliac artery aneurysm | 3 (0.5) |
| Endometrial | 3 (0.5) |
| Thickening | 1 |
| Mass | 2 |
| Mediastinal | 3 (0.5) |
| Cyst | 1 |
| Mass | 2 |
| Colon lesion | 2 (0.4) |
| Suspicious lymph node | 2 (0.4) |
| Pelvic mass | 2 (0.4) |
| Stomach mass | 1 (0.2) |
| Subclavian artery aneurysm | 1 (0.2) |
| Renal artery aneurysm | 1 (0.2) |
| Vertebral artery aneurysm | 1 (0.2) |
| Mesenteric mass | 1 (0.2) |
| Bladder mass | 1 (0.2) |
| Basal ganglia mass | 1 (0.2) |
Data are presented as N (%) of the total and n (%) of the class findings.
Subgroup classification of the incidental group
| Class 1 | Class 2 | Class 3 | p Value | |
| N | 53 | 207 | 125 | |
| Age (years) | 45.3±27.3 | 62.3±20.7 | 68.4±18.8 | <0.0001 |
| Elderly, ≥65 years | 19 (35.8) | 108 (52.2) | 77 (61.6) | 0.0067 |
| Injury severity score | 15.2±9.6 | 15.4±8.7 | 14.5±10.9 | 0.2144 |
| Trauma classification | 0.3015 | |||
| Fall | 24 (45.3) | 126 (60.9) | 88 (70.4) | |
| Motor vehicle accident | 20 (37.7) | 55 (26.6) | 24 (19.2) | |
| Pedestrian | 2 (3.8) | 5 (2.4) | 2 (1.6) | |
| Assault | 4 (7.5) | 10 (4.8) | 2 (1.6) | |
| Gunshot wound | 0 | 1 (0.5) | 0 | |
| Stab | 3 (5.7) | 10 (4.8) | 9 (7.2) | |
| Trauma type | 0.165 | |||
| Blunt | 50 (94.3) | 204 (98.6) | 124 (99.2) | |
| Penetrating | 1 (1.9) | 2 (1) | 0 | |
| Other | 2 (3.8) | 1 (0.48) | 1 (0.8) | |
| Discharge disposition | 0.9449 | |||
| Home | 31 (58.5) | 101 (48.8) | 55 (44) | |
| Rehab unit | 13 (24.5) | 47 (22.7) | 34 (27.2) | |
| Death | 5 (9.4) | 18 (8.7) | 14 (11.2) | |
| Skilled nursing facility | 2 (3.8) | 18 (8.7) | 10 (8) | |
| Against medical advice | 0 (0) | 4 (1.9) | 3 (2.4) | |
| Psychiatric unit | 1 (1.9) | 1 (0.48) | 1 (0.8) | |
| Other | 1 (1.9) | 18 (8.7) | 8 (6.4) | |
| ICU admission required | 20 (37.7) | 69 (33.3) | 40 (32) | 0.7574 |
| Hospital length of stay | 7.2±6.9 | 9.0±11 | 9.8±17 | 0.1206 |
Categorical data are presented as number (%) and continuous data as mean±SD.
ICU, intensive care unit.
Multivariate and OR analysis of length of stay, mortality and ICU admission
| Outcomes | p Value | |
| Length of stay (least square mean) | ||
| Incidental findings | 8.7±0.48 | 0.005 |
| Non-incidental findings | 6.7±0.55 | |
| Mortality | ||
| OR (no vs yes) | 0.77 (0.53, 1.11) | 0.164 |
| ICU admission | ||
| OR (no vs yes) | 0.74 (0.55, 1.00) | 0.053 |
The least square means and OR are adjusted for ISS, age, cardiopulmonary and prior surgery in a multivariate model for each of the outcomes. Least square means are presented with SEs. ORs are presented with 95% CIs.
ICU, intensive care unit; ISS, injury severity score.