Determinants of Hip and Femoral Deformities in Children With Spastic Cerebral Palsy.

OBJECTIVE: To find factors affecting hip and femoral deformities in children with spastic cerebral palsy (CP) by comparing various clinical findings with imaging studies including plain radiography and computed tomography (CT) imaging.
METHODS: Medical records of 709 children with spastic CP who underwent thorough baseline physical examination and functional assessment between 2 to 6 years old were retrospectively reviewed. Fifty-seven children (31 boys and 26 girls) who had both plain radiography of the hip and three-dimensional CT of the lower extremities at least 5 years after baseline examination were included in this study.
RESULTS: The mean age at physical examination was 3.6 years (SD=1.6; range, 2-5.2 years) and the duration of follow-up imaging after baseline examination was 68.4 months (SD=22.0; range, 60-124 months). The migration percentage correlated with motor impairment and the severity of hip adductor spasticity (R1 angle of hip abduction with knee flexion). The femoral neck and shaft angle correlated with the ambulation ability and severity of hip adductor spasticity (R1 and R2 angles of hip abduction with both knee flexion and extension).
CONCLUSION: Hip subluxation and coxa valga deformity correlated with both dynamic spasticity and shortening of hip adductor muscles. However, we found no correlation between femoral deformities such as femoral anteversion, coxa valga, and hip subluxation.

INTRODUCTION

Hip displacement and dislocation are common in children with cerebral palsy (CP) and are known to cause hip pain, severe contractures, windswept deformity, and motor disability [123]. Abnormal forces created by hip adductor muscles, followed by the influence of the hamstrings and iliopsoas have been suggested as the etiology of hip displacement [4]. It has been thought that these abnormal forces induced various abnormal deformities of the hip and femur such as excessive femoral anteversion and coxa valga, which resulted in hip displacement and dislocation. However, controversial results were also reported [145].

Femoral anteversion is defined as an anterior projection of the femoral head and neck relative to a plane in the femur in line with the femoral knee joint axis [4]. The range of femoral anteversion is 30°–40° at birth, which progressively decreases throughout growth to 15° by 16 years of age [67]. Children with spastic CP often show excessive femoral anteversion, however, the etiology is not clear. Some previous studies reported that at the functional level, fetal alignment and hip adductor spasticity could affect femoral anteversion in children with CP [67].

Coxa valga is an anatomical deformity where the femoral neck and shaft angle (FNS) exceeds normal limits; it has no recognizable cause or mechanism that can be assessed during physical examination. The FNS of infants is normally about 150°. With the influence of abductor force and walking, this gradually decreases to the normal adult range of 115° to 120° by 8 years of age. Most of this correction actually occurs by 2 to 3 years of age. However, many children with CP have some degree of coxa valga, which can be as severe as 180°, with 150° to 160° being relatively common in children with severe spasticity and the inability to bear weight [8]. Although this form of coxa valga has been attributed to spastic hip subluxation and dislocation, the current understanding is based on analyses of multiple factors rather than the etiology of dislocation [4].

Risk factors causing excessive femoral anteversion, coxa valga, and consequential hip subluxation have been reported rarely. Muscle spasticity, joint contractures, and functional impairments have been suggested as associated factors [91011].

The aim of this study was to determine factors affecting hip and femoral deformities of children with spastic CP by comparing various clinical findings with imaging studies taken at least 5 years after baseline examination.

MATERIALS AND METHODS

Medical records of 709 children between 2 to 6 years old with CP who underwent thorough baseline physical examination and functional assessment as part of a prebotulinum toxin injection evaluation were retrospectively reviewed (from 2005 to 2011). Ethical approval was granted by the Institutional Review Board (No. 4-2017-0167) and Ethics Committee of Severance Hospital. Of these, 60 children underwent three-dimensional computed tomography (3D CT) of the lower extremities and plain radiography of the hip at least 5 years after baseline examination as a pre-operative evaluation for orthopaedic surgery. Two children with additional dyskinetic features and one child without adequate imaging studies were excluded. Fifty-seven children (31 boys and 26 girls) who had undergone 3D CT of the lower extremities and plain radiography of the hip minimum 60 to maximum 124 months after baseline examination were included in this study. According to the Gross Motor Function Classification System (GMFCS), we classified children into the community ambulatory group (GMFCS I and II) and the non-community ambulatory group (GMFCS III-V). We selected the affected side for unilateral CP and the more spastic side, which means less angle of R1 of Modified Tardieu Scale (MTS), for bilateral CP.

Spasticity was measured using the MTS, which was developed by Tardieu et al. [12] in 1954 and later modified by Boyd and Graham [13]. Two angles of hip abduction with knee flexion and extension were measured after slow and fast stretches of the hip adductor muscles, referred to as R2 and R1 angles, respectively. Popliteal angles were also measured after slow and fast stretches of the hamstring muscles. R1 was assessed at the angle of each joint where a catch was first felt during a quick stretch of the joint. R2 was the passive range of motion at each joint [6].

The migration percentage (MP) and the FNS were measured from the anterior-posterior view of the radiograph (Fig. 1A, 1B). Femoral anteversion (FA) was measured from the 3D CT [4] (Fig. 1C). All measurements were performed by one of the authors (Y. Cho) to eliminate inter-rater variability [4]. Intra-rater reliability of hip and femoral deformity parameters are intraclass correlation coefficient (ICC) 0.96, 0.95, and 0.96 for MP, FNS, and FA.

Fig. 1

(A) Measurement of migration percentage (MP). MP=B/A×100. Hilgenreiner's line and Perkins line are marked as ‘H’ and ‘P’. MP is the proportion (%) of the capital epiphysis that appears to lie outside the acetabulum. (B) Measurement of the femoral neck and shaft angle (FNS). ‘a’ is the FNS measurement, performed in standard anterior-posterior X-rays of the proximal femur or pelvis, which was generated by the intersection angle between the femoral neck axis and femoral shaft axis. (C) Measurement of femoral anteversion, ‘b’ shows that the femoral anteversion is defined by the angle created by femoral neck axis and posterior condylar axis.

Statistical analyses

We compared the deformity parameters between clinical groups using Student t-test. In addition, we correlated clinical findings and radiologic deformity parameters using Pearson correlation. We used univariate linear regression to assess the relationship between clinical findings and radiologic deformity parameters. Also we calculated ICC to establish intra-rater reliability. Statistical analyses were performed using R v3.3.1 (R Foundation for Statistical Computing, http://www.R-project.org). A p-value of <0.01 was defined as statistically significant.

RESULTS

The demographic and baseline characteristics of the study population are shown in Table 1. Mean age at the time of baseline physical examination was 3.6 years (range, 2–6 years) and mean follow-up after baseline physical examination for imaging studies was 68.4 months (SD=22.0; range, 60–124 months). The percentage (number) of patients in GMFCS level I was 35.1% (n=20), level II was 22.8% (n=13), level III was 17.5% (n=10), level IV was 19.3% (n=11), and level V was 5.3% (n=3).

Table 1

Characteristics of participants (n=57)

Values are expressed as mean±standard deviation (range) or number of participants (%).

P/Ex, physical examination; GMFCS, Gross Motor Functional Classification System; MTS, Modified Tardieu Scale.

The MP was significantly higher in bilateral CP compared to unilateral CP. The FNS was significantly larger in the non-community ambulatory group compared to the community ambulatory group (p<0.01) (Table 2).

Table 2

Comparison of radiologic hip and femoral deformity parameters between clinical groups

Values are presented as mean±standard deviation.

P/Ex, physical examination.

*p<0.01, p-value for intergroup comparisons are derived by Student t-test.

The MP was inversely correlated with the R1 angle of hip abduction with knee flexion (coefficient=−0.378, p<0.01) (Table 3). The FNS was also inversely correlated with all hip abduction angles regardless of knee flexion or extension. However, there was no correlation between spasticity of the hip adductor muscles and FA. Furthermore, spasticity of hamstring muscles was not correlated with any radiologic parameter.

Table 3

Correlation between clinical findings at the age of physical examination and radiologic femoral and hip deformity parameters at the age of imaging study

MTS, Modified Tardieu Scale.

*p<0.01, **p<0.001.

We analyzed the relationship between clinical findings and radiologic hip and femoral deformity parameters using univariate linear regression (Table 4). The non-community ambulatory group had larger MP (β coefficient=15.83, p=0.003) and FNS (β coefficient=7.07, p=0.001) compared to the community ambulatory group. As the R1 angle of hip abduction with knee flexion decreased, the MP increased. However, the R1 angle of hip abduction with knee extension, R2 angles of hip abduction with both knee flexion and extension, and R1 and R2 of popliteal angles were not correlated with the MP. The larger FNS were correlated with smaller R1 and R2 angles of hip abduction regardless of knee position. FA angle was not correlated with any demographic or clinical findings. Finally, there was no correlation between radiologic femoral and hip deformity parameters (Table 5).

Table 4

iate linear regression for radiologic femoral and hip deformity parameters

SE, Standard error; MTS, Modified Tardieu Scale.

Table 5

Correlation between radiologic femoral and hip deformity parameters

Values are presented as Pearson correlation coefficients between radiologic femoral and hip deformity parameters.

DISCUSSION

Coxa valga has been defined as increased FNS [141516]. Several studies have reported the effects of age and sex on FNS [91011]. The FNS is largest during childhood and begins to decline during adolescence, slowing further during adulthood. Thus, with advancing age, there would be a minor decline in FNS [9]. Our study reported a similar trend in age, which was lower according to aging (p=0.012) (Table 4). Although FNS differences according to sex have not been clearly established, it was thought that there was no difference between genders [910]. However, one study reported that FNS was lower in females [11]. Our study also showed a similar tendency in the coxa valga deformity, which was lower in females (p=0.022) (Table 4).

The FNS was larger in the non-community ambulatory group in our study (p=0.001) (Table 2). This finding agreed with previous reports showing a positive correlation between FNS and GMFCS [1617]. Although one previous report commented that coxa valga was an acquired deformity according to the functional limitation, the reason why the FNS tended to increase with higher GMFCS level was not clearly established [17]. Therefore, further studies about the mechanism of coxa valga in children with CP should be performed.

FNS is associated with hypertonicity of hip adductor, hamstring, and iliopsoas muscles [141516]. We used MTS to measure both dynamic spasticity and shortening of hip adductor and hamstring muscles at baseline evaluation. With the MTS, two resulting joint angles can be measured using a goniometer; the R1 angle is the ‘angle of catch’ after a fast velocity stretch and the R2 angle is the passive joint range of movement following a slow velocity stretch [618]. Both dynamic spasticity and shortening of hip adductor muscles were significantly correlated with FNS although there was no correlation with hamstring muscles and FNS (Table 3). A linear relationship was found between hip adductor hypertonicity and FNS as well (Table 4). These results implied that reduction of hypertonicity of the hip adductor muscles could prevent the coxa valga deformity. However, further clinical studies are needed to confirm the effect of hypertonicity reduction on coxa valga deformity in children with CP.

FA was usually evaluated by clinical assessment using the trochanteric prominence angle test [81719]. However, these clinical methods had limitations in reliability and validity compared to measurement using 3D CT of the lower extremities [817]. FA is thought to interrupt hip abduction and lead to increased energy consumption during ambulation [19]. It has been thought that hip flexor tightness, imbalance of the hip rotators, weak abductors, and tight hamstring and adductor muscles were the factors affecting FA [19202122]. However, we did not find any correlation between FA and hypertonicity of the hip adductor and hamstring muscles in this study. The excessive hip flexion was thought to increase FA as well [23]. Unfortunately, hip flexor spasticity and tightness were not measured in medical records of this study. Further study is needed to evaluate the effect of hip flexors on FA.

Delayed weight bearing was also suggested as the reason for excessive FA [17212425]. Previous studies suggested that non-community ambulatory children with CP had a larger FA angle compared to community ambulatory children [7172226]. These results were also different from our conclusion (p=0.960) (Table 2).

Previous studies of clinical assessment using goniometry and plain radiography to measure FA might have had validity issues and confirmation bias [2021]. Some studies only recruited children with minor motor impairment such as GMFCS level I and II [26], and analyzed all types of CP including dystonic, hypotonic, ataxic, and mixed types [17]. And one hypothesis is many factors can affect in the FA, during aging process, but we examined clinically in young age and follow-up after at least 5 years. Many compounding factors could be influence on FA, but the factors were overlooked. Therefore, factors affecting FA should be studied further.

Hip displacement, which can be quantified by MP, is a common and severe problem in children with CP and can lead to hip dislocation with joint contracture, pain, and functional impairment [3]. The incidence of hip dislocation was higher in children with bilateral CP compared to those with unilateral CP [27]. The explanation was that extended upper limb impairment in children with bilateral involvement could raise the risk of hip displacement, and reduced weight bearing could affect the hip deformity in these children as well [27]. Our results showed a similar view where MP was larger in the bilateral involvement group compared to unilateral involvement group (p<0.01) (Table 2).

MP was greater in the non-community ambulatory group than the community ambulatory group, which meant that gross motor function could affect hip displacement (Table 4). Many previous results confirmed that non-community ambulatory children with severe motor impairment had an increased risk of hip displacement regardless of involvement side [1282930]. In addition, GMFCS levels were correlated with risk of hip displacement [331].

The spasticity of hip adductor muscles is also an important factor for hip displacement in children with CP [47323334]. Only the R1 angle of hip abduction with knee flexion, which reflected the spasticity of one-joint hip adductor muscles, correlated with MP in this study (Table 3). A linear relationship was also shown (Table 4).

Humans have several hip adductor muscles, including one-joint and two-joint muscles. One-joint muscles comprise the adductor longus and brevis, while two-joint muscles comprise the gracilis and adductor magnus muscles [73334]. During physical examination, we assessed hip spasticity with both knee flexion and extension. If there is no difference in spasticity with knee flexion and extension, one-joint muscles have more influence on spasticity. However, if hip adductor spasticity is more severe in knee extension, then two-joint muscles have more influence on spasticity [6]. Therefore, the major muscles affecting hip displacement are one-joint muscles, such as the adductor longus and brevis according to our study. The major surgical intervention of hip adductor spasticity in children with CP is to release the adductor longus and brevis muscles, which are one-joint muscles [3334]. In addition, only the R1 angle of hip abduction with knee flexion, and not the R2, correlated with MP. The R2 angle of MTS means the shortening of muscles, but R1 angle of MTS includes dynamic spasticity of muscles [61213]. This result may imply that reducing spasticity in one-joint hip adductor muscles can help to prevent hip subluxation in children with spastic CP [303435].

Hip displacement, coxa valga, and excessive FA are common in children with spastic CP [34]. In previous reports, there were many arguments regarding correlations with hip deformities [153637]. Some studies suggested that the hip displacement and FA were correlated [537]. Conversely, hip subluxation was reported not to correlate with FA, which was the same conclusion in our study [136]. However, the relationship between coxa valga and other hip and femoral deformities has not yet been reported. Our study revealed no correlation among all radiographic hip deformity parameters (Table 5). Further studies are still needed.

Many previous studies performed only cross-sectional analysis for hip and femoral deformities in children with CP, which indicated that the investigators performed physical examinations and imaging studies at a similar time [1151627313637]. The strengths of the present study were that the effects of clinical parameters of young children were analyzed with imaging studies that were taken after more than 5 years of follow-up. Between 60 and 124 months, children in this study grew up and underwent rehabilitation under very different conditions, which could affect hip and femoral deformity in each child differently. Despite many possible confounding factors which could weaken the effects on bone deformations, our results showed strong associations between MP and dynamic spasticity of one-joint hip adductor muscles, and between FNS and dynamic spasticity and shortening of both one-joint and two-joint hip adductor muscles with high statistical significance.

In conclusion, our study indicated that hip displacement and coxa valga deformity were correlated with gross motor function impairment, dynamic spasticity, and shortening of hip adductor muscles; however, FA was not correlated with clinical parameters. Furthermore, radiographic hip and femoral deformity parameters were not correlated each other.